{
  "abstract": "Background Prior to the onset of overt ventilatory failure, patients with Duchenne Muscular Dystrophy (DMD) can display non-uniform respiratory mechanics, resulting from atelectasis in small lung regions secondary to rapid, shallow breathing and/or peripheral airway obstruction, thereby predisposing to the development of ventilation inhomogeneity.Objectives To investigate ventilation distribution in DMD patients before the initiation of long-term assisted ventilation by using electrical impedance tomography (EIT).Methods Patients and interventions: Eighteen DMD patients underwent EIT between 1 January and 31 December 2025. Primary study endpoint: Global Inhomogeneity Index (GI). EIT data were compared with those obtained from a group of 11 healthy, similarly aged male medical residents.Results GI was significantly higher in the DMD patients with respect to healthy males [0.44 ± 0.13 (0.36–0.77) vs 0.37 ± 0.03 (0.32–0.43); p < 0.001]. A GI of 0.5 maximised the distinction between DMD patients with a ventilation distribution pattern similar to or different from the healthy subjects.Conclusions Before initiation of assisted ventilation, a subset of DMD patients may develop lung ventilation inhomogeneity, which can be readily assessed by means of EIT. Whether such inhomogeneity is predictive of major clinical events therefore constitutes a critical question to be addressed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy",
    "Department of Neurosciences, University of Padova, Padova, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Andrea Vianello"
    },
    {
      "affs": [
        0
      ],
      "name": "Federico Lionello"
    },
    {
      "affs": [
        0
      ],
      "name": "Michele Ciresi"
    },
    {
      "affs": [
        0
      ],
      "name": "Michela Pozza"
    },
    {
      "affs": [
        1
      ],
      "name": "Luca Bello"
    },
    {
      "affs": [
        0
      ],
      "name": "Gabriella Guarnieri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4sewzn0sh0zmc.bib",
  "cited_by": 0,
  "doi": "10.1080/25310429.2026.2753313",
  "fulltext_url": "https://www.tandfonline.com/doi/10.1080/25310429.2026.2753313",
  "id": "4sewzn0sh0zmc",
  "issns": [
    "2531-0437",
    "2531-0429"
  ],
  "landing_url": "https://doi.org/10.1080/25310429.2026.2753313",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC705-779"
    ],
    [
      "openalex",
      "2208|Electrical and Bioimpedance Tomography"
    ]
  ],
  "openalex": "W7223698128",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/25310429.2026.2753313?needAccess=true",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Taylor & Francis Group",
  "ris": "https://research.draconitic.com/paper/4sewzn0sh0zmc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:29Z",
      "native_id": "4a4133b32d7e456792994cd481dafba2",
      "source": "doaj",
      "url": "https://doi.org/10.1080/25310429.2026.2753313"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC705-779",
      "subfield": "general"
    }
  ],
  "title": "Ventilation inhomogeneity in Duchenne muscular dystrophy before the initiation of ventilatory support: Insights from electrical impedance tomography",
  "title_text": "Ventilation inhomogeneity in Duchenne muscular dystrophy before the initiation of ventilatory support: Insights from electrical impedance tomography",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:29Z",
  "url": "https://research.draconitic.com/paper/4sewzn0sh0zmc",
  "venue": "Pulmonology",
  "versions": []
}