{
  "abstract": "Background: Disseminated fusariosis is a serious fungal infection that primarily affects severely immunocompromised individuals. While it is well recognized in patients with hematologic malignancies and hematopoietic stem cell transplants (HSCT), it occurs far less frequently in solid organ transplant (SOT) recipients. Central nervous system (CNS) involvement is a rare clinical manifestation of disseminated fusariosis and has been scarcely reported in SOT recipients.\n\nCase Summary: We report the first case of disseminated fusariosis with CNS involvement manifesting as intracranial bleeding in a heart transplant recipient. This is a 48-year-old male with non-ischemic cardiomyopathy with reduced ejection fraction (<15%) and an implantable cardioverter-defibrillator (ICD) placed >10 years ago, admitted with cardiogenic shock status post impella device placement, followed by orthotopic heart transplant. Hospital stay was complicated by a spontaneous large intraparenchymal hemorrhage within the right parieto-occipital lobe measuring 4.7 × 3.3 × 4.8 cm on day 43 of admission, followed by acute respiratory arrest and hemodynamic instability on day 65 requiring intubation and vasopressors. Blood cultures and CSF cultures revealed Fusarium falciforme. A thorough skin examination revealed several dark lesions, mainly over his thighs bilaterally, along with bilateral toenail changes concerning for onychomycosis. The patient received treatment with intravenous amphotericin (10 mg/kg/day) and voriconazole (4 mg/kg twice daily), but he rapidly decompensated and passed away.\n\nConclusion: While fusariosis is more prevalent among HSCT recipients, SOT patients remain at risk, and the outcomes of infection in this population can be equally devastating. Hence, early recognition and rapid initiation of antifungal therapy are crucial to improve patients’ outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA",
    "Clinical Microbiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nour El Meski",
      "orcid": "0009-0006-1922-3978"
    },
    {
      "affs": [
        0
      ],
      "name": "Praveen Gundelly",
      "orcid": "0000-0003-4223-0712"
    },
    {
      "affs": [
        1
      ],
      "name": "Sree Sarah Cherian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4sfnbhznn3hxw.bib",
  "cited_by": 0,
  "doi": "10.1128/asmcr.00056-26",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729751/?tool=EBI",
  "id": "4sfnbhznn3hxw",
  "issns": [
    "2996-2684"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729751",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Infectious Disease Case Reports"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W7214126852",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729751/pdf/?tool=EBI",
  "pmcid": "PMC13729751",
  "pmid": "42979129",
  "published": "2026-09-23",
  "publisher": "American Society for Microbiology (ASM)",
  "ris": "https://research.draconitic.com/paper/4sfnbhznn3hxw.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13729751",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729751"
    },
    {
      "first_seen": "2026-11-07T12:22:30Z",
      "native_id": "PMC13729751",
      "source": "pmc",
      "url": "https://doi.org/10.1128/asmcr.00056-26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Disseminated fusariosis presenting as intracranial bleeding in a heart transplant recipient",
  "title_text": "Disseminated fusariosis presenting as intracranial bleeding in a heart transplant recipient",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:30Z",
  "url": "https://research.draconitic.com/paper/4sfnbhznn3hxw",
  "venue": "ASM case reports",
  "versions": []
}