{
  "abstract": "(R)-Citronellal, a key intermediate for (-)-menthol and other valuable fragrance compounds, is traditionally synthesized by unsustainable chemical methods, with low selectivity. Herein, we report a one-pot enzymatic cascade converting geraniol to enantiopure (R)-citronellal using Streptomyces hiroshimensis aryl-alcohol oxidase ShAAO and ene reductase Saccharomyces cerevisiae OYE2_Y83V. A scale-up reaction at 100 mM geraniol produced 95 mg of (R)-citronellal with an enantiomeric excess of >99.8%, demonstrating a sustainable, preparative-scale, and highly selective route to chiral terpenoids.",
  "abstract_shown": true,
  "affiliations": [
    "Biocatalysis Section, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZDelft, Netherlands.",
    "Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009Zaragoza, Spain.",
    "Instituto de Biocomputación y Física de Sistemas Complejos, BIFI (GBsC-CSIC Joint Unit), Universidad de Zaragoza, 50018Zaragoza, Spain.",
    "Department of Organic and Inorganic Chemistry, IUQEM, University of Oviedo, Julián Clavería 8, 33006Oviedo, Spain."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Claudia Ferrer-Carbonell"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christian Ascaso-Alegre"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Paula Cinca-Fernando",
      "orcid": "0000-0003-4929-9595"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Patricia Ferreira"
    },
    {
      "affs": [
        3
      ],
      "name": "Juan Mangas-Sánchez",
      "orcid": "0000-0002-3364-1512"
    },
    {
      "affs": [
        0
      ],
      "name": "Caroline E Paul",
      "orcid": "0000-0002-7889-9920"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4t6vma3j947n7.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c02985",
  "fulltext_url": "https://europepmc.org/articles/PMC13595905",
  "id": "4t6vma3j947n7",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42918086",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Enzyme Catalysis and Immobilization"
    ]
  ],
  "openalex": "W7212050795",
  "pdf_url": "https://europepmc.org/articles/PMC13595905?pdf=render",
  "pmcid": "PMC13595905",
  "pmid": "42918086",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4t6vma3j947n7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42918086",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42918086"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Enzyme Catalysis and Immobilization",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Biocatalytic Cascade from Geraniol to Enantiopure (R)-Citronellal Using an Aryl-Alcohol Oxidase and Ene Reductase.",
  "title_text": "Biocatalytic Cascade from Geraniol to Enantiopure (R)-Citronellal Using an Aryl-Alcohol Oxidase and Ene Reductase.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/4t6vma3j947n7",
  "venue": "Organic letters",
  "versions": []
}