{
  "abstract": "Background Patients with venous thromboembolism (VTE) receive anticoagulation for at least 3 months. To evaluate recurrence risk thereafter, some strategies include D-dimer testing after discontinuing anticoagulation, which raises concern about early recurrence. Objectives To assess the incidence of recurrent VTE within 30 days after stopping anticoagulation. Methods We conducted a systematic review of EMBASE, CENTRAL, and MEDLINE to identify controlled trials and cohort studies of adult noncancer patients with deep vein thrombosis of the leg and/or pulmonary embolism treated with anticoagulants for ≥3 months. The primary outcome was symptomatic VTE within 30 days. The risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale. Pooled recurrence rates were calculated using fixed random-effects meta-analyses. Results Of 42 studies, 24 (57%) provided data, encompassing 11,407 patients. Early recurrence occurred in 115 patients (1.01%), with a pooled incidence of 1.04% (95% CI, 0.8%-1.4%). Men had a risk similar to that of women (risk ratio, 1.2; 95% CI, 0.6-2.3; P = .7). Unprovoked VTE was associated with a 2.6-fold increase in risk (95% CI, 1.4-4.6; P < .001) compared with provoked VTE. Patients with deep vein thrombosis at presentation had a similar risk of recurrence compared with those with an incident pulmonary embolism (risk ratio, 0.6; 95% CI: 0.3-1.2; P = .1). Findings regarding age were inconsistent. None of the recurrences was fatal. The overall risk of bias was low. Conclusion The incidence of early VTE recurrence after stopping anticoagulation is low. Temporarily discontinuing therapy to assess recurrence risk, therefore, appears safe and may aid in guiding treatment duration.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "name": "Lisbeth Eischer"
    },
    {
      "name": "Paul A Kyrle"
    },
    {
      "name": "Alexandra Kaider"
    },
    {
      "name": "Anton Schmidt"
    },
    {
      "name": "Brigitte Wildner"
    },
    {
      "name": "Anja Boc"
    },
    {
      "name": "Charlotte Bradbury"
    },
    {
      "name": "Anetta Undas"
    },
    {
      "name": "Francis Couturaud"
    },
    {
      "name": "Matteo Nicola Dario Di Minno"
    },
    {
      "name": "Geert-Jan Geersing"
    },
    {
      "name": "David Jimenez"
    },
    {
      "name": "Sameer Parpia"
    },
    {
      "name": "Gualtiero Palareti"
    },
    {
      "name": "Daniela Poli"
    },
    {
      "name": "Daniel P Potaczek"
    },
    {
      "name": "Paolo Prandoni"
    },
    {
      "name": "Sam Schulman"
    },
    {
      "name": "Astrid van Hylckama Vlieg"
    },
    {
      "name": "Michal Zabczyk"
    },
    {
      "name": "Sabine Eichinger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4temrn0ws6r65.bib",
  "cited_by": 1,
  "doi": "10.1016/j.rpth.2025.103317",
  "fulltext_url": null,
  "id": "4temrn0ws6r65",
  "issns": [
    "2475-0379",
    "2475-0379"
  ],
  "landing_url": "https://univ-brest.hal.science/hal-05733784v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2724|Venous Thromboembolism Diagnosis and Management"
    ]
  ],
  "openalex": "W7117473086",
  "pdf_url": "https://univ-brest.hal.science/hal-05733784/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/4temrn0ws6r65.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "hal-05733784",
      "source": "hal",
      "url": "https://univ-brest.hal.science/hal-05733784v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "The incidence of early recurrent venous thromboembolism: a systematic review and meta-analysis",
  "title_text": "The incidence of early recurrent venous thromboembolism: a systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/4temrn0ws6r65",
  "venue": "Research and Practice in Thrombosis and Haemostasis",
  "versions": []
}