{
  "abstract": "Postoperative urinary retention (POUR) is a common complication of surgery and anesthesia, with an incidence of 4–5% in elective procedures. POUR is traditionally managed with bladder catheterization, which carries risks of infection, urethral trauma, and prolonged hospitalization. Pharmacologic alternatives such as alpha-adrenergic antagonists or cholinergic agonists have been trialed, but with variable efficacy. Neostigmine, an acetylcholinesterase inhibitor, enhances parasympathetic activity to promote detrusor contraction and may represent a noninvasive treatment option, although its use in POUR is rarely reported. We report the case of a 73-year-old male with a history of benign prostatic hyperplasia (BPH), bladder cancer status-post transurethral resection of bladder tumor (TURBT), and interstitial pulmonary fibrosis, who presented for magnetic resonance image (MRI)-guided transperineal prostate biopsy. The procedure was performed under general anesthesia and tolerated without complication. Postoperatively, the patient developed acute urinary retention with a bladder volume of 565 mL that persisted for over 5 h despite ambulation, caffeine, and tamsulosin administration. Wishing to avoid catheterization, the patient elected to trial neostigmine after a risk-benefit-alternatives discussion. A 0.5 mg intravenous injection of neostigmine was administered. Complete voiding occurred within 20 min after the injection without adverse hemodynamic effects, and the patient was discharged home promptly. This case illustrates a temporal association between neostigmine administration and resolution of POUR; a single case cannot establish efficacy or causation.",
  "abstract_shown": true,
  "affiliations": [
    "University of South Florida Morsani College of Medicine",
    "Department of Anesthesiology and Perioperative Medicine, University of South Florida Morsani College of Medicine",
    "TeamHealth Anesthesia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mitch Daniel"
    },
    {
      "affs": [
        1
      ],
      "name": "Victoria Martin"
    },
    {
      "affs": [
        1
      ],
      "name": "John Hodgson"
    },
    {
      "affs": [
        2
      ],
      "name": "Tanjina Jalil"
    },
    {
      "affs": [
        1
      ],
      "name": "Enrico Camporesi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4tnrgbz39xqk4.bib",
  "cited_by": 0,
  "doi": "10.1007/s44337-026-00729-y",
  "fulltext_url": "https://doi.org/10.1007/s44337-026-00729-y",
  "id": "4tnrgbz39xqk4",
  "issns": [
    "3004-8885"
  ],
  "landing_url": "https://doi.org/10.1007/s44337-026-00729-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2748|Urinary Bladder and Prostate Research"
    ]
  ],
  "openalex": "W7223152483",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s44337-026-00729-y.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "Springer Nature",
  "ris": "https://research.draconitic.com/paper/4tnrgbz39xqk4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:27Z",
      "native_id": "da79367f55c74f74a058be7f42ccfa46",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s44337-026-00729-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Urinary Bladder and Prostate Research",
      "subfield": "general"
    }
  ],
  "title": "Case report of postoperative urinary retention resolution following neostigmine administration in a patient with multiple risk factors for POUR",
  "title_text": "Case report of postoperative urinary retention resolution following neostigmine administration in a patient with multiple risk factors for POUR",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:27Z",
  "url": "https://research.draconitic.com/paper/4tnrgbz39xqk4",
  "venue": "Discover Medicine",
  "versions": []
}