{
  "abstract": "Acute kidney injury (AKI) is a critical clinical challenge for which effective pharmacological therapies remain limited. Inflammation and oxidative stress play central roles in its pathogenesis. Here, we investigated the effects of Stachybotrys microspora triprenyl phenol-44D (SMTP-44D), a soluble epoxide hydrolase inhibitor that, unlike its analog SMTP-7, lacks thrombolytic activity, in a mouse model of renal ischemia-reperfusion (I/R)-induced AKI. SMTP-44D was administered either during or prior to ischemia. SMTP-44D improved renal functional parameters, including blood urea nitrogen, serum creatinine, and fractional sodium excretion in both protocols, with a protocol-dependent difference in creatinine clearance. An attenuation of tubular morphological alterations was observed when SMTP-44D was administered during ischemia, whereas pre-ischemic administration failed to demonstrate apparent morphological improvement. Mechanistic analysis was conducted using the pre-ischemic administration protocol. Urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule 1 were significantly reduced. SMTP-44D also suppressed renal tumor necrosis factor alpha, interleukin-1 beta, and NADPH oxidase-1 levels. Collectively, these functional and molecular findings suggest that SMTP-44D provides anti-inflammatory and antioxidant renoprotection, while evidence supporting structural protection is lacking in the pre-ischemic administration protocol. SMTP-44D warrants further investigation as a potential therapeutic strategy for I/R-induced AKI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology, Graduate School of Pharmacy, Showa University, Tokyo 142-8555, Japan.",
    "Pharmacological Research Center, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.",
    "Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan.",
    "Division of Research and Development, TMS Co., Ltd., Fuchu, Tokyo 183-0055, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Keita Shibata",
      "orcid": "0000-0002-3935-8742"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Keiji Hasumi",
      "orcid": "0000-0002-3340-7312"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Koji Nobe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4tpe2s8gc864c.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198506",
  "fulltext_url": "https://europepmc.org/articles/PMC13664903",
  "id": "4tpe2s8gc864c",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883755",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7214231075",
  "pdf_url": "https://europepmc.org/articles/PMC13664903?pdf=render",
  "pmcid": "PMC13664903",
  "pmid": "42883755",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4tpe2s8gc864c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883755",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883755"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "SMTP-44D Attenuates Renal Inflammatory/Oxidative Dysfunction in a Mouse Model of Ischemia-Reperfusion-Induced Acute Kidney Injury.",
  "title_text": "SMTP-44D Attenuates Renal Inflammatory/Oxidative Dysfunction in a Mouse Model of Ischemia-Reperfusion-Induced Acute Kidney Injury.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/4tpe2s8gc864c",
  "venue": "International journal of molecular sciences",
  "versions": []
}