{
  "abstract": "Colorectal cancer (CRC) is one of the most diagnosed malignancies worldwide, with chronic inflammation playing a critical role in its pathogenesis and progression. Surgery represents the primary treatment option, though some patients suffer from relapse, leading to considerable morbidity and mortality. A better molecular understanding of CRC pathogenesis is therefore essential for identifying patients at increased risk of recurrence and improving clinical management. Here we identified the X-linked inhibitor of apoptosis protein (XIAP) as an independent predictor of overall survival in primary resected CRC patients. To model CRC patients with low versus high XIAP expression, we established conditional mouse lines for intestinal epithelial cell (IECs)-specific Xiap knock-out and XIAP knock-in, and employed a colitis-associated murine model for CRC. We found that XIAP promotes inflammatory signalling and exacerbates colitis-driven colorectal tumorigenesis by shaping a distinct tumor inflammatory microenvironment characterized by increased immune-cell infiltration, including neutrophils, and enhanced vascularisation. The pro-inflammatory role of XIAP was further validated in CRC patient-derived organoids and human CRC tumor specimens. Collectively, our findings identify XIAP as a potential biomarker of CRC-associated inflammation and a candidate marker for identifying patients at increased risk of disease recurrence. Moreover, these results provide a rationale for exploring XIAP-targeting strategies as a potential component of multimodal therapeutic approaches for CRC.",
  "abstract_shown": true,
  "affiliations": [
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department of General, Visceral, Thoracic and Transplantation Surgery, Cologne, Germany. lars.schiffmann@uk-koeln.de.",
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, Cologne, Germany.",
    "Max Planck Institute for Metabolism Research, Department of Obesity and Cancer, Cologne, Germany.",
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department of General, Visceral, Thoracic and Transplantation Surgery, Cologne, Germany.",
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Pathology, Cologne, Germany.",
    "University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.",
    "University Hospital Heidelberg, University Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg, Germany.",
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department of Neurosurgery, Cologne, Germany.",
    "University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany.",
    "Immunology and Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.",
    "University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 33,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lars M Schiffmann",
      "orcid": "0000-0002-2320-5004"
    },
    {
      "affs": [
        1
      ],
      "name": "Mila Daoud",
      "orcid": "0000-0002-8705-5869"
    },
    {
      "affs": [
        2
      ],
      "name": "Claudia Maria Wunderlich"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabian Schorn"
    },
    {
      "affs": [
        1
      ],
      "name": "Johanna Stachelscheid",
      "orcid": "0000-0001-7419-8900"
    },
    {
      "affs": [
        1
      ],
      "name": "Pia Nora Broxtermann"
    },
    {
      "affs": [
        1
      ],
      "name": "Marie-Christine Albert"
    },
    {
      "affs": [
        3
      ],
      "name": "M Siebenbürger"
    },
    {
      "affs": [
        4
      ],
      "name": "Heike Göbel",
      "orcid": "0000-0002-0171-7025"
    },
    {
      "affs": [
        5
      ],
      "name": "Ulrike Göbel"
    },
    {
      "affs": [
        5
      ],
      "name": "Ali T Abdallah"
    },
    {
      "affs": [
        1
      ],
      "name": "J Paul Werthenbach"
    },
    {
      "affs": [
        1
      ],
      "name": "Jens Michael Seeger",
      "orcid": "0000-0002-3192-9192"
    },
    {
      "affs": [
        3
      ],
      "name": "Naita M Wirsik"
    },
    {
      "affs": [
        3
      ],
      "name": "Karl Knipper"
    },
    {
      "affs": [
        4
      ],
      "name": "Su Ir Lyu"
    },
    {
      "affs": [
        3
      ],
      "name": "Thomas Schmidt"
    },
    {
      "affs": [
        3
      ],
      "name": "Nikolai Schleußner"
    },
    {
      "affs": [
        6
      ],
      "name": "Uraz Yasar"
    },
    {
      "affs": [
        3
      ],
      "name": "Christian Goddemeier"
    },
    {
      "affs": [
        7
      ],
      "name": "Stephanie T Jünger"
    },
    {
      "affs": [
        3
      ],
      "name": "Hans A Schlößer"
    },
    {
      "affs": [
        3
      ],
      "name": "Georg Dieplinger"
    },
    {
      "affs": [
        8
      ],
      "name": "Thomas Zander"
    },
    {
      "affs": [
        3
      ],
      "name": "Hakan Alakus"
    },
    {
      "affs": [
        3
      ],
      "name": "Hans F Fuchs"
    },
    {
      "affs": [
        3
      ],
      "name": "Florian Gebauer"
    },
    {
      "affs": [
        3
      ],
      "name": "Christiane J Bruns",
      "orcid": "0000-0001-6590-8181"
    },
    {
      "affs": [
        9
      ],
      "name": "Domagoj Vucic",
      "orcid": "0000-0003-3614-8093"
    },
    {
      "affs": [
        4
      ],
      "name": "Alexander Quaas"
    },
    {
      "affs": [
        1
      ],
      "name": "Melanie Fritsch"
    },
    {
      "affs": [
        2
      ],
      "name": "Frank Thomas Wunderlich"
    },
    {
      "affs": [
        1,
        5,
        10
      ],
      "name": "Hamid Kashkar",
      "orcid": "0000-0003-2796-1429"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4tv4y4919rnf9.bib",
  "cited_by": 0,
  "doi": "10.1038/s41419-026-09391-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13728099",
  "id": "4tv4y4919rnf9",
  "issns": [
    "2041-4889"
  ],
  "landing_url": "https://europepmc.org/article/MED/42971958",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2730|Colorectal Cancer Treatments and Studies"
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  "openalex": "W7225128352",
  "pdf_url": "https://europepmc.org/articles/PMC13728099?pdf=render",
  "pmcid": "PMC13728099",
  "pmid": "42971958",
  "published": "2026-11-02",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/4tv4y4919rnf9.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42971958",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42971958"
    },
    {
      "first_seen": "2026-11-06T12:23:50Z",
      "native_id": "PMC13728099",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41419-026-09391-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Treatments and Studies",
      "subfield": "oncology"
    }
  ],
  "title": "XIAP induces inflammation and promotes colorectal cancer progression.",
  "title_text": "XIAP induces inflammation and promotes colorectal cancer progression.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:09Z",
  "url": "https://research.draconitic.com/paper/4tv4y4919rnf9",
  "venue": "Cell death & disease",
  "versions": []
}