{
  "abstract": "Despite modeling-based epidemiological studies of MASLD, precise estimates of the prevalence and health-care resource utilization in outpatient clinical practice are unknown. We assessed, in a real-life setting, the prevalence of suspected/confirmed MASLD and described health-care resource utilization. A prospective, observational study of patients attending the outpatient hepato-gastroenterology clinics of eight European tertiary care centers during three months. Follow-up data of patients with suspected/confirmed MASLD were recorded 12 months after the screening visit: final diagnosis, disease stage, diagnostic work-up and the use of health-care resources. 5240 outpatients from Germany, France, United Kingdom, Switzerland, Italy, Spain and Slovakia were screened. The main reasons for visit were: chronic viral hepatitis, 33.4% (1749/5240), miscellaneous hepatobiliary conditions including neoplasms, 32.9% (1725/5240) and known/suspected MASLD, 24.7% (1293/5240) (pooled prevalence of 26.1% (95% CI: 19.1-34.7)). 1134 suspected/confirmed MASLD patients were included, the diagnosis was confirmed in 80.2% (909/1134). Significant fibrosis was documented in 22.7% (257/1134) and cirrhosis (including burn-out MASLD) in 21.3% (241/1134). Procedures performed differed between countries, overall 66.4% (753/1134) had imaging studies, 65.3% (740/1134) non-invasive fibrosis tests, 20.4% (231/1134) liver biopsy, while referral for further cardiometabolic assessment or therapy was minimal (144/1134, 15.8%). The cost of all procedures and visits was in the range of that recommended for exploring hepatitis C before treatment, although highly variable between countries. MASLD was the second most frequent single cause for outpatient visits in eight European tertiary care centers. Significant fibrosis including cirrhosis was diagnosed in 44% of patients. The cost of required additional visits and procedures was equivalent to that recommended for hepatitis C before antiviral treatment. IMI2-Grant Agreement 777377-LITMUS.",
  "abstract_shown": true,
  "affiliations": [
    "Sorbonne Université, Paris, France.",
    "ICAN Institute for Cardiometabolism and Nutrition, Paris, France.",
    "Assistance Publique-Hôpitaux de Paris, Hepatogastroenterology Department, Pitié-Salpêtrière Hospital, Paris, France.",
    "INSERM UMRS 1138 CRC, Paris, France.",
    "Inselspital, Universitätsspital Bern, Bern, Switzerland.",
    "Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.",
    "Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.",
    "Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.",
    "2nd Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, 04011, Kosice, Slovakia.",
    "Department of Internal Medicine, Hospital Poprad, Slovakia.",
    "Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Sevilla, Spain.",
    "Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.",
    "Department of Medicine, University Medical Centre Mainz, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Vlad Ratziu"
    },
    {
      "affs": [
        4
      ],
      "name": "Jean-François Dufour"
    },
    {
      "affs": [
        1
      ],
      "name": "Maharajah Ponnaiah"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Raluca Pais"
    },
    {
      "affs": [
        4
      ],
      "name": "Maximilian Thormann"
    },
    {
      "affs": [
        5
      ],
      "name": "Elisabetta Bugianesi"
    },
    {
      "affs": [
        6
      ],
      "name": "Fabio Marra"
    },
    {
      "affs": [
        7
      ],
      "name": "Marie Boyle"
    },
    {
      "affs": [
        7
      ],
      "name": "Kate Hallsworth"
    },
    {
      "affs": [
        6
      ],
      "name": "Silvia Aspite"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Sylvia Drazilova"
    },
    {
      "affs": [
        5
      ],
      "name": "Federico Ravaioli"
    },
    {
      "affs": [
        10
      ],
      "name": "Manuel Romero Gomez"
    },
    {
      "affs": [
        1
      ],
      "name": "Leila Kara"
    },
    {
      "affs": [
        7,
        11
      ],
      "name": "Quentin M Anstee"
    },
    {
      "affs": [
        12
      ],
      "name": "Jörn Schattenberg"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4twdd9889x4kp.bib",
  "cited_by": 0,
  "doi": "10.1016/j.lanepe.2026.101893",
  "fulltext_url": "https://europepmc.org/articles/PMC13743415",
  "id": "4twdd9889x4kp",
  "issns": [
    "2666-7762"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999578",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2721|Liver Disease Diagnosis and Treatment"
    ]
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  "openalex": "W7224649553",
  "pdf_url": "https://europepmc.org/articles/PMC13743415?pdf=render",
  "pmcid": "PMC13743415",
  "pmid": "42999578",
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4twdd9889x4kp.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999578",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999578"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Health-care burden of metabolic dysfunction-associated steatotic liver disease in European tertiary-care outpatient clinics (CONSTANS): a prospective multicentre cohort study.",
  "title_text": "Health-care burden of metabolic dysfunction-associated steatotic liver disease in European tertiary-care outpatient clinics (CONSTANS): a prospective multicentre cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/4twdd9889x4kp",
  "venue": "The Lancet regional health. Europe",
  "versions": []
}