{
  "abstract": "Intrinsically disordered regions (IDRs) are widely recognized as facilitators of chromatin regulation. However, their potential role as regulatory restraints remains poorly understood. Here, we reveal that the C-terminal IDR of mammalian ALKBH5 anchors its main activity to mRNA, limiting chromatin engagement in mouse embryonic stem cells (mESCs). IDR deletion redirects ALKBH5 to chromatin-associated non-coding RNAs, driving widespread chromatin opening and transcriptional activation. This mechanism extends to histone demethylases, where IDR deletion also results in broad removal of repressive histone marks, leading to increased chromatin accessibility and activation of transposable elements (TEs). Building on these insights, we applied IDR deletion to engineer ALKBH5 and its plant homologs. Overexpression of these IDR-deleted ALKBH5 demethylases enhanced Arabidopsis root growth and markedly increased rice yield. Our findings uncover a conserved role for IDRs in restraining chromatin access by RNA and histone demethylases and establish a strategy to reprogram chromatin through endogenous plant proteins for crop improvement.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA",
    "Howard Hughes Medical Institute, Chicago, IL 60637, USA",
    "These authors contributed equally",
    "Department of Chemistry, Department of Biological Sciences, and Cancer Science Institute, National University of Singapore, Singapore",
    "School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China",
    "Sycamore Research Institute of Life Sciences, Shanghai, 201203, China",
    "Department of Chemistry, Fudan University, Shanghai, 200438, China",
    "Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA",
    "Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Liudan Jiang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Long Zhao"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Jiangbo Wei"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Bochen Jiang"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Yu Xiao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fan Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaolin Zeng"
    },
    {
      "affs": [
        0,
        1,
        7,
        8
      ],
      "name": "Chuan He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4v2m5bgbjq6y4.bib",
  "cited_by": 0,
  "doi": "10.1038/s41588-026-02685-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723049/",
  "id": "4v2m5bgbjq6y4",
  "issns": [
    "1061-4036",
    "1546-1718"
  ],
  "landing_url": "https://doi.org/10.1038/s41588-026-02685-w",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Epigenetics and DNA Methylation"
    ]
  ],
  "openalex": "W7170193562",
  "pdf_url": null,
  "pmcid": "PMC13723049",
  "pmid": "42493596",
  "published": "2026-07-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4v2m5bgbjq6y4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:43Z",
      "native_id": "PMC13723049",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41588-026-02685-w"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Epigenetics and DNA Methylation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants",
  "title_text": "Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:43Z",
  "url": "https://research.draconitic.com/paper/4v2m5bgbjq6y4",
  "venue": "Nature genetics",
  "versions": []
}