{
  "abstract": "Background\n\nImaging-based assessment of proliferative and molecular features in adult-type diffuse gliomas may support preoperative tumor characterization. This study evaluated conventional MRI combined with diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) for their associations with Ki-67 index, IDH status, and ATRX expression status.Materials and methods\n\nThis retrospective study included 126 patients with adult-type diffuse gliomas who underwent conventional MRI, DWI, and SWI; rCBV from DSC-PWI was available in 59 patients. Quantitative ADC and rCBV measurements were independently performed by two readers. Histopathological and molecular data were obtained from pathology reports. Ki-67 expression was dichotomized as low (< 10%) and high (≥ 10%). ROC analysis assessed the diagnostic performance of MRI parameters for high Ki-67 expression and WHO grade ≥ 3 tumors; sensitivity analyses were performed using alternative Ki-67 thresholds of ≥ 15%, ≥ 20%, ≥ 25%, and ≥ 30%. Potential selection bias related to rCBV availability was assessed, and multivariable logistic regression was performed.Results\n\nAmong 126 patients, 84.1% had WHO grade 4 tumors. ADCmin, rADCmin, ADCmean, and rADCmean were significantly lower, whereas rCBVmax and ITSS grade were significantly higher, in tumors with high Ki-67 expression (all p < 0.001). High Ki-67 expression was also associated with necrosis, peritumoral edema, and heterogeneous enhancement. ADC-derived parameters differed significantly between IDH-mutant and IDH-wildtype tumors. rCBVmax was higher in tumors with retained ATRX expression (p = 0.016). rCBVmax showed the highest diagnostic performance for high Ki-67 expression (AUC = 0.967; 95% CI: 0.920-1.000). In multivariable analysis, lower ADCmin and rADCmin remained independently associated with high Ki-67 expression, whereas ITSS grade did not. Interobserver agreement was excellent for quantitative ADC and rCBV measurements.Conclusion\n\nMultiparametric MRI features, particularly diffusion-derived metrics and rCBVmax, were associated with proliferative activity in adult-type diffuse gliomas and may support preoperative noninvasive tumor characterization, but validation in larger and more balanced cohorts is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Fahrettin Kerim Gokay Street No:161 Kadikoy, İstanbul, 34722, Türkiye.",
    "Department of Radiology, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Fahrettin Kerim Gokay Street No:161 Kadikoy, İstanbul, 34722, Türkiye. baysalbegumhan@yahoo.com.",
    "Department of Pathology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Türkiye.",
    "Department of Neurosurgery, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Muhammet Arif Kursun"
    },
    {
      "affs": [
        1
      ],
      "name": "Begumhan Baysal"
    },
    {
      "affs": [
        2
      ],
      "name": "Gulnihal Ay"
    },
    {
      "affs": [
        3
      ],
      "name": "Fatih Calis"
    },
    {
      "affs": [
        3
      ],
      "name": "Mehmet Sabri Gurbuz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4v6b4az7wzygp.bib",
  "cited_by": 0,
  "doi": "10.1186/s12880-026-02607-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13700258",
  "id": "4v6b4az7wzygp",
  "issns": [
    "1471-2342"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928153",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7170187313",
  "pdf_url": "https://europepmc.org/articles/PMC13700258?pdf=render",
  "pmcid": "PMC13700258",
  "pmid": "42928153",
  "published": "2026-07-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4v6b4az7wzygp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:20Z",
      "native_id": "MED:42928153",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928153"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Multiparametric MRI with DWI, SWI, and DSC-PWI for preoperative prediction of Ki-67, IDH, and ATRX in adult-type diffuse gliomas.",
  "title_text": "Multiparametric MRI with DWI, SWI, and DSC-PWI for preoperative prediction of Ki-67, IDH, and ATRX in adult-type diffuse gliomas.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:20Z",
  "url": "https://research.draconitic.com/paper/4v6b4az7wzygp",
  "venue": "BMC medical imaging",
  "versions": []
}