{
  "abstract": "A low-cost, easy-to-adopt noninvasive imaging modality for differentiating bacterial infection from inflammation is desirable to accurately diagnose bacterial infections. Herein, a bacteria-specific PET probe, [68Ga]-Ga-BP, was developed and evaluated in rat models of foreign body-associated osteomyelitis induced by methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae and was directly compared with sterile inflammation and uninstrumented uninfected controls. [68Ga]-Ga-BP-based imaging of MRSA-infected tibiae was also compared to [68Ga]-Ga-citrate and [18F]-FDG. After iron depletion, dynamic PET/CT imaging was performed at 15-120 min postinjection of radiotracers, followed by assessment of ex vivo biodistribution. [68Ga]-Ga-BP successfully detected tibial infection and demonstrated >6-fold higher uptake in infected tibiae with all three bacterial species versus contralateral tibiae via PET imaging. [68Ga]-Ga-BP outperformed [68Ga]-Ga-citrate and [18F]-FDG in identifying MRSA infection. [68Ga]-Ga-BP represents a promising, noninvasive PET imaging agent for direct bacterial detection and bacterial infection treatment monitoring.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, United States.",
    "Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota 55905, United States.",
    "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, United States.",
    "Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota 55905, United States.",
    "Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota 55905, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Mukesh K Pandey",
      "orcid": "0000-0002-2332-5305"
    },
    {
      "affs": [
        0
      ],
      "name": "Aditya Bansal"
    },
    {
      "affs": [
        0
      ],
      "name": "Shalini Sharma"
    },
    {
      "affs": [
        3
      ],
      "name": "Melissa Karau",
      "orcid": "0000-0001-6021-4033"
    },
    {
      "affs": [
        3
      ],
      "name": "Yash S Raval",
      "orcid": "0000-0003-1161-4000"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephen M Broski",
      "orcid": "0000-0001-5391-9537"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Robin Patel",
      "orcid": "0000-0001-6344-4141"
    },
    {
      "affs": [
        0
      ],
      "name": "Mark Nathan"
    },
    {
      "affs": [
        0
      ],
      "name": "Val J Lowe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4vd39dx4ggebv.bib",
  "cited_by": 0,
  "doi": "10.1021/cbmi.6c00082",
  "fulltext_url": "https://europepmc.org/articles/PMC13714943",
  "id": "4vd39dx4ggebv",
  "issns": [
    "2832-3637"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953237",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W7163888689",
  "pdf_url": "https://europepmc.org/articles/PMC13714943?pdf=render",
  "pmcid": "PMC13714943",
  "pmid": "42953237",
  "published": "2026-06-08",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/4vd39dx4ggebv.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953237",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953237"
    },
    {
      "first_seen": "2026-11-01T12:22:20Z",
      "native_id": "PMC13714943",
      "source": "pmc",
      "url": "https://doi.org/10.1021/cbmi.6c00082"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiopharmaceutical Chemistry and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "PET Imaging of Osteomyelitis with [⁶⁸Ga]Ga-BP.",
  "title_text": "PET Imaging of Osteomyelitis with [⁶⁸Ga]Ga-BP.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:20Z",
  "url": "https://research.draconitic.com/paper/4vd39dx4ggebv",
  "venue": "Chemical & biomedical imaging",
  "versions": []
}