{
  "abstract": "High-dimensional microscopy captures features across space, time, and spectrum, but complex backgrounds obscure signals. We present Background2Background (B2B), a self-supervised background removal framework leveraging the backgrounds larger correlation relative to the signal. Local pixel shuffling disrupts signal correlations while preserving background structure, transforming signals into effective noise for Noise2Noise-based background removal. Across fluorescence, stimulated Raman scattering and mid-infrared photothermal imaging, B2B achieves over 40-fold background suppression and reveals hidden signatures.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.17615",
  "author_total": 11,
  "authors": [
    {
      "name": "Guangrui Ding"
    },
    {
      "name": "Haonan Lin"
    },
    {
      "name": "Rong Tang"
    },
    {
      "name": "Bethany Weinberg"
    },
    {
      "name": "Jianpeng Ao"
    },
    {
      "name": "Qing Xia"
    },
    {
      "name": "Guorong Hu"
    },
    {
      "name": "Dingcheng Sun"
    },
    {
      "name": "Jiaze Yin"
    },
    {
      "name": "Lei Tian"
    },
    {
      "name": "Ji-Xin Cheng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4vj2zfycg9c62.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.17615",
  "fulltext_url": null,
  "id": "4vj2zfycg9c62",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.17615",
  "language": null,
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "cs.CV"
    ],
    [
      "arxiv",
      "eess.IV"
    ],
    [
      "arxiv",
      "physics.optics"
    ],
    [
      "openalex",
      "1707|Image and Signal Denoising Methods"
    ]
  ],
  "openalex": "W7221836457",
  "pdf_url": "https://arxiv.org/pdf/2610.17615",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4vj2zfycg9c62.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:11Z",
      "native_id": "2610.17615",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.17615"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.optics",
      "subfield": "optics-photonics"
    }
  ],
  "title": "Background2Background: a self-supervised background removal framework for high dimensional microscopy",
  "title_text": "Background2Background: a self-supervised background removal framework for high dimensional microscopy",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:11Z",
  "url": "https://research.draconitic.com/paper/4vj2zfycg9c62",
  "venue": "arXiv",
  "versions": []
}