{
  "abstract": "目的: 比较手术取精与射精取精应用于卵胞质内单精子注射（ICSI）辅助生育对3~6岁子代智力和体格发育影响的差异。\n\n方法: 纳入在浙江大学医学院附属妇产科医院生殖中心行辅助生殖技术助孕并成功分娩的5481名3~6岁子代，其中ICSI手术取精组305名、ICSI射精取精组1131名、常规体外受精（IVF）射精组4045名。以IVF射精取精组作为参照，考察ICSI射精取精组及ICSI手术取精组子代智力和体格发育结局。结局指标包括言语智商、操作智商、全量表智商、智力低下（全量表智商低于70），以及低体重、生长迟缓、消瘦、超重、肥胖等。采用广义估计方程校正家庭内相关性及混杂因素，并在单胎子代中（n=3295）进行敏感性分析。\n\n结果: ICSI手术取精组母亲年龄、母亲身高、母亲体重、母亲体重指数、父亲年龄、父亲身高及精子浓度、精子活力低于ICSI射精取精组（均P<0.017），原发不孕比例、妊娠期贫血发生率高于ICSI射精取精组（均P<0.017）。ICSI手术取精组子代肥胖风险高于ICSI射精取精组（OR=1.94，95%CI：1.09~3.48，P=0.025），经Bonferroni校正后处于临界水平（校正后P=0.050）；智力和其他体格发育结局差异均无统计学意义（均P>0.05）。敏感性分析结果显示，ICSI手术取精组子代肥胖风险同样呈增高趋势（OR=2.15，95%CI：1.03~4.36，P=0.043），经Bonferroni校正后差异无统计学意义（校正后P=0.086）。ICSI射精取精组与IVF射精取精组子代所有结局差异均无统计学意义（校正后均P>0.05）。\n\n结论: 射精取精与手术取精后ICSI对3~6岁子代智力及体格发育无明显影响。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "欢苗 严",
      "orcid": "0000-0002-5222-2057"
    },
    {
      "name": "敏悦 唐"
    },
    {
      "name": "敏 魏"
    },
    {
      "name": "依敏 朱",
      "orcid": "0000-0002-9667-3677"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4vpqhqs3rrtqk.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2026-0760",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722848/",
  "id": "4vpqhqs3rrtqk",
  "issns": [
    "1008-9292"
  ],
  "landing_url": "https://doi.org/10.3724/zdxbyxb-2026-0760",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ],
    [
      "heading",
      "R711.6"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "2735|Assisted Reproductive Technology and Twin Pregnancy"
    ]
  ],
  "openalex": "W7222143018",
  "pdf_url": null,
  "pmcid": "PMC13722848",
  "pmid": "42881127",
  "published": "2026-09-25",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/4vpqhqs3rrtqk.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:35Z",
      "native_id": "PMC13722848",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2026-0760"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Assisted Reproductive Technology and Twin Pregnancy",
      "subfield": "reproductive-child"
    }
  ],
  "title": "手术取精应用于卵胞质内单精子注射对3~6岁子代智力和体格发育的影响",
  "title_text": "手术取精应用于卵胞质内单精子注射对3~6岁子代智力和体格发育的影响",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:35Z",
  "url": "https://research.draconitic.com/paper/4vpqhqs3rrtqk",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}