{
  "abstract": "Background\n\nFall-risk-increasing drugs (FRIDs) may contribute to a higher falls-risk in older people, but research examining standardised screening tools is limited.Objectives\n\nTo examine FRID prevalence in community-dwelling older adults, any association with subsequent fall-related hospital admissions, and FRID prescriptions before and after admission.Design\n\nRetrospective cohort study.Subjects/setting\n\nAdults aged ≥65 years across 44 general practices in Ireland.Methods\n\nFourteen FRIDs, defined by Screening Tool of Older Persons Prescriptions in older adults with high Fall risk (STOPPFall) criteria, were examined as time-varying exposures from 2012 to 2016. The association between FRID exposure and fall-related admissions was estimated using Cox proportional hazards models, adjusted for relevant confounders. Participants' FRID use pre- and post-fall-related admission was analysed descriptively.Findings\n\nOf the 35 942 participants, 16 780 (47%) were prescribed at least one long-term FRID at baseline, and 867 (2.4%) experienced a subsequent fall-related admission. Long-term FRID use was associated with a higher risk of fall-related admission [adjusted hazard ratio (aHR) 2.85, 95% CI 2.13-3.82, P < .001], demonstrating a stronger association with an increasing FRID burden-one FRID: aHR 2.81 (95% CI 2.07-3.82, P < .001); ≥5 FRIDs: 5.67 (95% CI 3.70-8.70, P < .001). Long-term FRID prevalence measured pre- and post-fall-related admission was unchanged (53.9%-53.2%). A total of 148 (19.5%) participants had a FRID discontinued, 86 (11.3%) were prescribed an additional FRID and 110 (14.5%) had a FRID initiated for the first time.Conclusion\n\nFRID use, defined via STOPPFall, was prevalent in older adults and associated with a substantially increased risk of injurious falls. FRID use remained unchanged following discharge. Guidelines recommend including medication review in fall-risk assessments, but further work is needed to embed this across health systems.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Practice, School of Medicine, University College Cork, Cork, Ireland.",
    "School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.",
    "Department of Public Health and Epidemiology, School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland.",
    "Department of General Practice, RCSI University of Medicine and Health Sciences, Dublin, Ireland.",
    "Department of Medicine, School of Medicine, University College Cork, Cork, Ireland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Steven Gilmore",
      "orcid": "0009-0006-5823-9614"
    },
    {
      "affs": [
        1
      ],
      "name": "Ann Sinéad Doherty",
      "orcid": "0000-0003-4149-1574"
    },
    {
      "affs": [
        1
      ],
      "name": "Frank Moriarty",
      "orcid": "0000-0001-9838-3625"
    },
    {
      "affs": [
        2
      ],
      "name": "Fiona Boland",
      "orcid": "0000-0003-3228-0046"
    },
    {
      "affs": [
        3
      ],
      "name": "Caroline McCarthy",
      "orcid": "0000-0002-2986-5994"
    },
    {
      "affs": [
        1
      ],
      "name": "Ryan Muddiman",
      "orcid": "0000-0001-9369-749X"
    },
    {
      "affs": [
        2
      ],
      "name": "Barbara Clyne",
      "orcid": "0000-0002-1186-9495"
    },
    {
      "affs": [
        3
      ],
      "name": "Tom Fahey",
      "orcid": "0000-0002-5896-5783"
    },
    {
      "affs": [
        4
      ],
      "name": "Denis O'Mahony",
      "orcid": "0000-0003-2236-5222"
    },
    {
      "affs": [
        0
      ],
      "name": "Emma Wallace",
      "orcid": "0000-0002-9315-2956"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4vr0kesctj9a4.bib",
  "cited_by": 0,
  "doi": "10.1093/ageing/afag303",
  "fulltext_url": "https://europepmc.org/articles/PMC13693591",
  "id": "4vr0kesctj9a4",
  "issns": [
    "0002-0729",
    "1468-2834"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912565",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2717|Pharmaceutical Practices and Patient Outcomes"
    ]
  ],
  "openalex": "W7223349028",
  "pdf_url": "https://europepmc.org/articles/PMC13693591?pdf=render",
  "pmcid": "PMC13693591",
  "pmid": "42912565",
  "published": "2026-08-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4vr0kesctj9a4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42912565",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912565"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2717|Pharmaceutical Practices and Patient Outcomes",
      "subfield": "general"
    }
  ],
  "title": "Fall-risk-increasing drug use in older community-dwelling adults: prevalence, association with fall-related admissions and post-discharge prescribing changes-a retrospective cohort study.",
  "title_text": "Fall-risk-increasing drug use in older community-dwelling adults: prevalence, association with fall-related admissions and post-discharge prescribing changes-a retrospective cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/4vr0kesctj9a4",
  "venue": "Age and ageing",
  "versions": []
}