{
  "abstract": "Background\n\nTo evaluate the effects of scaling and root planing (SRP) on stage of hepatic steatosis measured by abdominal ultrasound (US) in patients affected by Metabolic Associated Fatty Liver Disease (MAFLD) and periodontitis.Methods\n\nIn this preliminary retrospective observational study, 205 adult patients affected by equivalent steatosis grade ≥ 1 and periodontitis grade ≥ 1 were included. Patients' baseline characteristics included age, comorbidities and biochemical parameters (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase). Baseline periodontal grade was assessed using periodontal probing depth and grade of hepatic steatosis was assessed using abdominal US. Patients were subjected to periodontal treatment consisting in SRP, in addition to oral hygiene recommendations and the Mediterranean diet. After 6 months, the grade of hepatic steatosis was re-evaluated by an abdominal US. Statistical analysis with Pearson's Chi-squared test was performed. This research received approval from the Ethics Committee.Results\n\nNo significant correlation was observed between MAFLD severity and periodontitis stage. At 6 months follow-up, the degree of hepatic steatosis at abdominal US was significantly reduced in 89.8% of patients (p-value < 0.001), regardless of the grade of hepatic steatosis. No adverse events were reported.Conclusion\n\nNon-surgical periodontal treatment consisting in SRP induced a significant short-term reduction of hepatic steatosis at abdominal US. Further research is mandatory to define SRP efficacy and safety in patients with MAFLD, and periodontitis.Trial registration\n\nThe Ethics Committee of the University of Bari approved the study (Prot. no. 502 of 16.07.2024 Secretariat of the Local Ethics Committee. Prot. 1737 /CEL - Periodontal Treatment Study\"). Local Ethics Committee meeting of July 15, 2024 (Puglia Region Regional Council Resolution No. 712 of May 22, 2023, and Amendment No. 806 of June 12, 2023).",
  "abstract_shown": true,
  "affiliations": [
    "Department of Interdisciplinary Medicine, University of Bari \"Aldo Moro\", Bari, 70124, Italy.",
    "Department of Interdisciplinary Medicine, University of Bari \"Aldo Moro\", Bari, 70124, Italy. alessiodanilo.inchingolo@uniba.it.",
    "PTA Trani-ASL BT, Viale Padre Pio, Trani, 76125, Italy.",
    "Department of Forensic Odontology, Section of Legal Medicine, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.",
    "Department of Economics and Finance, University of Bari \"Aldo Moro\", Bari, 70124, Italy.",
    "Department of Interdisciplinary Medicine, University of Bari \"Aldo Moro\", Bari, 70124, Italy. vito.crincoli@aslbat.it.",
    "Department of Experimental Medicine, University of Salento, Lecce, 73100, Italy.",
    "Department of Interdisciplinary Medicine, University of Bari \"Aldo Moro\", Bari, 70124, Italy. angelomichele.inchigolo@uniba.it."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gianna Dipalma"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessio Danilo Inchingolo"
    },
    {
      "affs": [
        2
      ],
      "name": "Bruno Modesti"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura Ferrante"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucia Casamassima"
    },
    {
      "affs": [
        0
      ],
      "name": "Irma Trilli"
    },
    {
      "affs": [
        3
      ],
      "name": "Emilio Nuzzolese"
    },
    {
      "affs": [
        2
      ],
      "name": "Francesco Galante"
    },
    {
      "affs": [
        4
      ],
      "name": "Caterina Marini"
    },
    {
      "affs": [
        5
      ],
      "name": "Vito Crincoli"
    },
    {
      "affs": [
        6
      ],
      "name": "Andrea Palermo"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesco Inchingolo"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Celeste Fatone"
    },
    {
      "affs": [
        7
      ],
      "name": "Angelo Michele Inchingolo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4vt7gkza4rr0q.bib",
  "cited_by": 0,
  "doi": "10.1186/s12903-026-09408-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13726280",
  "id": "4vt7gkza4rr0q",
  "issns": [
    "1472-6831"
  ],
  "landing_url": "https://europepmc.org/article/MED/42968060",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
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      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7172432883",
  "pdf_url": "https://europepmc.org/articles/PMC13726280?pdf=render",
  "pmcid": "PMC13726280",
  "pmid": "42968060",
  "published": "2026-08-05",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/4vt7gkza4rr0q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42968060",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42968060"
    },
    {
      "first_seen": "2026-11-05T12:22:39Z",
      "native_id": "PMC13726280",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12903-026-09408-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease.",
  "title_text": "Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:17Z",
  "url": "https://research.draconitic.com/paper/4vt7gkza4rr0q",
  "venue": "BMC oral health",
  "versions": []
}