{
  "abstract": "Double umbilical cord blood (dUCB) allogeneic transplantation after a low-dose total body irradiation, cyclophosphamide, and fludarabine (TCF)-based reduced-intensity conditioning regimen (RIC) is increasingly used in adults lacking a suitable related or unrelated donor. Currently, there are little data regarding the long-term outcome of CD3(+) T cell chimerism (TCC) in this particular setting. Thirty-six adults with various hematological diseases who received dUCB allogeneic transplants conditioned with TCF were included in this retrospective study. Peripheral blood CD3(+) TCC was considered until day +100 after transplantation to determine the impact of full versus mixed chimerism on long-term outcomes. Twenty-nine and 7 patients were documented with full and mixed CD3(+) TCC, respectively, within the first 100 days after transplantation. With a median follow-up of 36 months, 3 year-overall survival (OS), disease-free survival (DFS), and cumulative incidence of relapse (CIR) were 61%, (95% confidence interval [CI], 43% to 75%); 50% (95% CI, 32.5% to 66%), and 28% (95% CI, 16% to 44%), respectively. In univariate analysis, a full CD3(+) TCC was associated with a better 3-year DFS: 59% (95% CI, 39% to 75.5%) versus 14% (95% CI, 7% to 46%); hazard ratio (HR), .24 (.09 to .65); P = .005 and a lower CIR: 24% (95% CI, 21.5% to 57%) versus 78% (95% CI, 52% to 99%); HR, .18 (.05 to .50); P = .004. In multivariate analysis, a full CD3(+) TCC remained associated with a lower CIR (HR, .17 [.028 to .99]; P = .049). CD3(+) TCC has no impact on graft-versus-host disease and nonrelapse mortality in this study. In conclusion, here, full CD3(+) TCC was independently associated with a lower risk of relapse in adults receiving a dUCB TCF RIC allogeneic transplantation. This highlights the need to develop immunotherapy approaches allowing for early conversion to full chimerism after this type of transplantation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Pierre Peterlin"
    },
    {
      "name": "Jacques Delaunay"
    },
    {
      "name": "Thierry Guillaume"
    },
    {
      "name": "Thomas Gastinne"
    },
    {
      "name": "Béatrice Mahé"
    },
    {
      "name": "Viviane Dubruille"
    },
    {
      "name": "Nicolas Blin"
    },
    {
      "name": "Amandine Le Bourgeois"
    },
    {
      "name": "Eolia Brissot"
    },
    {
      "name": "Laurence Lodé"
    },
    {
      "name": "Steven Le Gouill"
    },
    {
      "name": "Philippe Moreau"
    },
    {
      "name": "Mohamad Mohty"
    },
    {
      "name": "Patrice Chevallier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4w26grsb5ef8n.bib",
  "cited_by": 17,
  "doi": "10.1016/j.bbmt.2014.08.018",
  "fulltext_url": null,
  "id": "4w26grsb5ef8n",
  "issns": [
    "1083-8791",
    "1523-6536"
  ],
  "landing_url": "https://nantes-universite.hal.science/hal-05745265v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W2067953661",
  "pdf_url": "https://nantes-universite.hal.science/hal-05745265/document",
  "pmcid": null,
  "pmid": "25175796",
  "published": "2026-09-10",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4w26grsb5ef8n.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "hal-05745265",
      "source": "hal",
      "url": "https://nantes-universite.hal.science/hal-05745265v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "Complete Donor T Cell Chimerism Predicts Lower Relapse Incidence after Standard Double Umbilical Cord Blood Reduced-Intensity Conditioning Regimen Allogeneic Transplantation in Adults",
  "title_text": "Complete Donor T Cell Chimerism Predicts Lower Relapse Incidence after Standard Double Umbilical Cord Blood Reduced-Intensity Conditioning Regimen Allogeneic Transplantation in Adults",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/4w26grsb5ef8n",
  "venue": "Biology of Blood and Marrow Transplantation",
  "versions": []
}