{
  "abstract": "Spondyloarthritis is a multi-faceted condition housing a group of inter-related chronic inflammatory rheumatic diseases such as ankylosing spondylitis, IBD-associated arthritis, psoriatic arthritis and juvenile idiopathic arthritis. While decades of research and technological advancements have significantly improved our understanding of the disease, there remain many underlying genetic and physiological mechanisms which are unsolved but essential for the development of the right diagnosis and treatment. This mini-review examines our current foundational knowledge of spondyloarthritis, the main concepts related to the disease pathogenesis and the various lines of therapies developed thus far. We hope to provide a perspective on the current and potential antibody discovery platforms for the next decade as computational methods and artificial intelligence become increasingly mature and relevant in clinical research.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Translational Research, Singapore General Hospital, Outram Rd, Singapore 169608, Singapore.",
    "School of Biomedical Science and Pharmacy, Newcastle Australia Institute of Higher Education, 100 Victoria St, #13-01/02, Singapore 188064, Singapore.",
    "Medicine Academic Clinical Programme, Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kwai Wei Chan"
    },
    {
      "affs": [
        1
      ],
      "name": "Ghee Chong Koo",
      "orcid": "0000-0001-6569-0098"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Che Kang Lim",
      "orcid": "0000-0002-3361-0900"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4w755jb62da79.bib",
  "cited_by": 0,
  "doi": "10.3390/antib15050090",
  "fulltext_url": "https://europepmc.org/articles/PMC13700759",
  "id": "4w755jb62da79",
  "issns": [
    "2073-4468"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930032",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
    ]
  ],
  "openalex": "W7220431778",
  "pdf_url": "https://europepmc.org/articles/PMC13700759?pdf=render",
  "pmcid": "PMC13700759",
  "pmid": "42930032",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4w755jb62da79.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930032",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930032"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Spondyloarthritis Studies and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Antibody Discovery and Therapeutics in Spondyloarthritis: Recent Advances and Future Directions.",
  "title_text": "Antibody Discovery and Therapeutics in Spondyloarthritis: Recent Advances and Future Directions.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/4w755jb62da79",
  "venue": "Antibodies (Basel, Switzerland)",
  "versions": []
}