{
  "abstract": "Objectives Low-grade appendiceal mucinous neoplasms (LAMNs) are rare tumors with potential progression to pseudomyxoma peritonei (PMP). The optimal management of patients without macroscopic peritoneal disease remains debated. We previously reported 3-year outcomes of an active surveillance (AS) strategy. This study evaluates the 5-year results of the same cohort. Methods This prospective observational study was conducted at a tertiary referral center. Patients with histologically confirmed LAMN, normal postoperative MRI and tumor markers, and limited or no extra-appendiceal mucin were enrolled in an AS protocol. Surveillance included clinical examination, serum tumor markers, and abdominopelvic MRI at 6 months and annually thereafter. Disease progression was defined as histologically proven PMP. Results Among the 30 patients initially included, 25 completed a mean 5-year follow-up and 5 were excluded after exceeding 75 years of age. No new PMP cases occurred among patients disease-free at 3 years. All four patients previously suspected of radiologic progression underwent cytoreduction and HIPEC; only two (8 %) had histologically confirmed low-grade PMP and achieved remission after complete cytoreduction. Two cases were false-positive imaging findings. Conclusions After 5 years, active surveillance remains a safe and effective long-term strategy for selected patients with LAMN, supporting conservative MRI-based follow-up and avoiding unnecessary aggressive surgery.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Christian Mouawad"
    },
    {
      "name": "Armelle Bardier"
    },
    {
      "name": "Olivier Lucidarme"
    },
    {
      "name": "Solène Doat"
    },
    {
      "name": "Dahbia Djelil"
    },
    {
      "name": "Jade Fawaz"
    },
    {
      "name": "Marc Pocard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4w87xjxy9efqw.bib",
  "cited_by": 0,
  "doi": "10.1515/pp-2025-0043",
  "fulltext_url": null,
  "id": "4w87xjxy9efqw",
  "issns": [
    "2364-7671",
    "2364-768X"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05749112v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.heg"
    ],
    [
      "openalex",
      "2746|Intraperitoneal and Appendiceal Malignancies"
    ]
  ],
  "openalex": "W7212405466",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-14",
  "publisher": "Walter de Gruyter GmbH",
  "ris": "https://research.draconitic.com/paper/4w87xjxy9efqw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "hal-05749112",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05749112v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Intraperitoneal and Appendiceal Malignancies",
      "subfield": "surgery"
    }
  ],
  "title": "Active surveillance strategy for low-grade appendiceal mucinous neoplasm (LAMN): 5-year results",
  "title_text": "Active surveillance strategy for low-grade appendiceal mucinous neoplasm (LAMN): 5-year results",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/4w87xjxy9efqw",
  "venue": "Pleura and peritoneum",
  "versions": []
}