{
  "abstract": "The green synthesis of zirconia nanoparticles (N-ZrO2 NPs) with plant extracts offers a unique and ecologically benign approach for biological applications. In this study, dried leaf extract of Azadirachta indica was employed as a reducing and capping agent in the manufacture of N-ZrO2 nanoparticles. The Fourier transform infrared (FT-IR) study reveals the presence of functional bonds necessary for NP stabilization, while X-ray diffraction (XRD) studies validate the crystalline structure and phase purity. The shape and morphology of N-ZrO2 NPs were analyzed by Transmission electron microscopy (TEM) investigations. It was observed that the prepared NPs had an average size of 8.15 ± 0.25 nm. The synthesized N-ZrO2 NPs shows antibacterial activity against both Gram-positive and Gram-negative bacteria and strong antibiofilm activity against Staphylococcus aureus. Biofilm inhibition reached 71.5%% at 1⋅MIC, with 30.6% reduction in biofilm biomass at higher concentration, confirming dose-dependent disruption of biofilm architecture. The NPs also showed notable antioxidant activity in DPPH and H2O2 scavenging assays. Cytotoxicity tests show dose-dependent anti-cancer efficacy against MCF-7 breast cancer cells, with an IC50 of 38.69 µg/mL. However, no appreciable antifungal activity was detected. These findings demonstrate the efficacy of green-synthesized N-ZrO2 NPs as antibacterial, antibiofilm, antioxidant, and anticancer agents in biomedical applications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, Taywade College",
    "Ramdeobaba University",
    "Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Deemed to be University",
    "Department of Physics, R.T.M. Nagpur University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shruti N. Tanwar"
    },
    {
      "affs": [
        1
      ],
      "name": "Yatish R. Parauha"
    },
    {
      "affs": [
        0
      ],
      "name": "Yogesh There"
    },
    {
      "affs": [
        2
      ],
      "name": "Anil Pethe"
    },
    {
      "affs": [
        3
      ],
      "name": "S. J. Dhoble"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4watjjx3dkz3y.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-62317-5",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-62317-5",
  "id": "4watjjx3dkz3y",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-62317-5",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2505|Nanoparticles: synthesis and applications"
    ]
  ],
  "openalex": "W7170077076",
  "pdf_url": "https://www.nature.com/articles/s41598-026-62317-5_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/4watjjx3dkz3y.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:58Z",
      "native_id": "b27804859eb5476ea608dff112f77871",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-62317-5"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Nanoparticles: synthesis and applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Green synthesis of zirconium oxide nanoparticles using Azadirachta indica leaves extract for multifunctional biomedical applications",
  "title_text": "Green synthesis of zirconium oxide nanoparticles using Azadirachta indica leaves extract for multifunctional biomedical applications",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:58Z",
  "url": "https://research.draconitic.com/paper/4watjjx3dkz3y",
  "venue": "Scientific Reports",
  "versions": []
}