{
  "abstract": "Stem cell factor (SCF) and its receptor c-Kit regulate the development, survival, tissue localization, and activation of several immune populations central to allergic disease. This review examines how the SCF220 and SCF248 isoforms shape c-Kit signaling in mast cells, group 2 innate lymphoid cells, eosinophils, dendritic cells, and basophils; how stromal and epithelial sources of SCF sustain allergic inflammation; and how this pathway contributes to disease severity and tissue remodeling. We also discuss the therapeutic potential and limitations of targeting SCF, or specific SCF isoforms, in allergic disease.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, University of Michigan Medical School",
    "Mary H. Weiser Food Allergy Center, University of Michigan"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ramon Ocadiz-Ruiz"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarita Montaño"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nicholas W. Lukacs"
    },
    {
      "affs": [
        0
      ],
      "name": "Wendy Fonseca"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4wbnas10sax0p.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.2009363",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2009363/full",
  "id": "4wbnas10sax0p",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2009363/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC581-607"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4wbnas10sax0p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:19Z",
      "native_id": "10.3389/fimmu.2026.2009363",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2009363/full"
    },
    {
      "first_seen": "2026-10-31T14:22:33Z",
      "native_id": "08e02a6020fc497696b103bccb574667",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fimmu.2026.2009363"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "lcc:RC581-607",
      "subfield": "general"
    }
  ],
  "title": "Stem cell factor in allergic diseases: mechanisms of type 2 immunity and therapeutic opportunities",
  "title_text": "Stem cell factor in allergic diseases: mechanisms of type 2 immunity and therapeutic opportunities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:33Z",
  "url": "https://research.draconitic.com/paper/4wbnas10sax0p",
  "venue": "Frontiers in Immunology",
  "versions": []
}