{
  "abstract": "Introduction: ROAM/EORTC-1308 is an international (Europe and Australasia) phase III randomised controlled trial (RCT) comparing radiotherapy (60Gy/30#) to observation after surgery for WHO grade 2 atypical meningioma. The treatment plans of all the patients randomised to radiotherapy were reviewed and approved prior to treatment delivery. Pretrial credentialling included outlining and planning a benchmark case. Materials and methods: Variations from the guidelines were noted in QA reports both for the Benchmark Case (BM) and for on-trial Individual Case Reviews (ICRs). After the trial, the QA reports were used to analyse the variations in the BM and ICRs. A random 10% of the ICRs were reviewed again independently. In all cases the reviewer agreed with the original decision. Results: 58 centres opened, of which 56 centres (20 UK, 25 EORTC, 11 TROG) submitted BM. Two centres did not undergo radiotherapy credentialling and closed without recruiting any patients. Resubmissions were: 4 (7%) for outlining and 11 (20%) for planning. During the trial 66 patients at 28 centres received radiotherapy, (median 2 patients per site). Resubmissions for ICRs were: 31 (48%) sets of outlines (3 cases twice) and 12 (18%) treatment plans (1 plan twice). There were 28 instances of major variations in the ICR outlines and 14 in the ICR plans. Conclusions: For complex radiotherapy of uncommon tumours, a pre-trial QA is insufficient and prospective ICRs of all patients are required. The consistent high-quality radiotherapy in ROAM/EORTC1308 ensures the primary outcome is robust and that there was no variation in radiotherapy treatment across sites.",
  "abstract_shown": true,
  "affiliations": [
    "The Clatterbridge Cancer Centre NHS Foundation Trust, Clatterbridge Road, Bebington, CH63 4JY, UK; National Radiotherapy Trials Quality Assurance (RTTQA) Group, UK; Corresponding author at: Five Oaks, Street Hey Lane, Willaston, CH64 1SS.7196, United Kingdom.",
    "The Clatterbridge Cancer Centre NHS Foundation Trust, Clatterbridge Road, Bebington, CH63 4JY, UK",
    "The Christie NHS Foundation Trust, 550 Wilmslow Road, Withington, Manchester, M20 4BX, UK",
    "Center for Proton Therapy, Paul Scherrer Institut, Switzerland",
    "The University of Liverpool, Liverpool, L69 7ZX, UK"
  ],
  "article_type": "research article",
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  "author_total": 8,
  "authors": [
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      "name": "Helen M.O. Mayles"
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    {
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      "name": "Brian J. Haylock"
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    {
      "affs": [
        2
      ],
      "name": "Gillian Whitfield"
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    {
      "affs": [
        1
      ],
      "name": "Shaveta Mehta"
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    {
      "affs": [
        1
      ],
      "name": "Alice Brain"
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    {
      "affs": [
        1
      ],
      "name": "Robert Brass"
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    {
      "affs": [
        3
      ],
      "name": "Damien C. Weber"
    },
    {
      "affs": [
        4
      ],
      "name": "Michael D. Jenkinson"
    }
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  "bibtex": "https://research.draconitic.com/paper/4wc75ebkav3ye.bib",
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  "doi": "10.1016/j.ctro.2026.101322",
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  "landing_url": "https://doi.org/10.1016/j.ctro.2026.101322",
  "language": "en",
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  "pdf_url": "https://www.ctro.science/article/S2405-6308(26)00217-X/pdf",
  "pmcid": "PMC13718502",
  "pmid": "42959875",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4wc75ebkav3ye.ris",
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  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3108|Advanced Radiotherapy Techniques",
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  ],
  "title": "Radiation therapy quality assurance (RT QA) of adjuvant fractionated radiotherapy for WHO grade 2 atypical meningioma in the ROAM/EORTC1308 trial",
  "title_text": "Radiation therapy quality assurance (RT QA) of adjuvant fractionated radiotherapy for WHO grade 2 atypical meningioma in the ROAM/EORTC1308 trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:31Z",
  "url": "https://research.draconitic.com/paper/4wc75ebkav3ye",
  "venue": "Clinical and Translational Radiation Oncology",
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