{
  "abstract": "The gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. Closing this gap requires more than individual behavior change; it requires system-level solutions, including coverage and funding design, pharmacist-led programs, and health information technology.\n\nIn this Perspective, Zachary Marcum argues that the gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. He discusses why closing this gap requires not just individual behavior change, but system-level solutions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, United States of America"
  ],
  "article_type": "Perspective",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zachary A. Marcum"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4wcr5p9py8azp.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pmed.1005237",
  "fulltext_url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005237",
  "id": "4wcr5p9py8azp",
  "issns": [
    "1549-1676"
  ],
  "landing_url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005237",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ],
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      "/Medicine and health sciences/Pharmacology/Drugs/Anticoagulants"
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  "pdf_url": "https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1005237&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/4wcr5p9py8azp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pmed.1005237",
      "source": "plos",
      "url": "https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005237"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "plos:epidemiology",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "plos:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "The widening medication adherence gap",
  "title_text": "The widening medication adherence gap",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/4wcr5p9py8azp",
  "venue": "PLOS Medicine",
  "versions": []
}