{
  "abstract": "ObjectiveTrauma-induced coagulopathy (TIC) is a life-threatening complication associated with uncontrolled hemorrhage and high mortality in critically ill trauma patients. This study aimed to evaluate the associations and discriminative performance of four composite liver-function indices—ALBI, TBil/ALB, DBil/TBil, and GGT/ALP—with TIC-related outcomes in adult trauma patients.MethodologyThis single-center retrospective cohort study included 634 adult trauma patients. Laboratory data were collected at baseline, 24 h after admission, and 48 h after admission. The primary outcome was the continuous ISTH DIC score assessed 48 h after admission. Overt DIC, non-overt DIC, and ATC were analyzed as secondary or exploratory TIC-related outcomes. Multivariable models adjusted for age, sex, admission lactate, admission pH, admission temperature, traumatic brain injury, hepatic injury, and surgery. Associations between each index and TIC-related outcomes were examined using multivariable linear and logistic regression analyses.ResultsALBI showed the most consistent associations with TIC-related outcomes and the strongest index-alone discrimination for non-overt DIC among the evaluated indices. The TBil/ALB ratio retained independent predictive value, though with somewhat lower overall consistency. The DBil/TBil and GGT/ALP ratios, by contrast, exhibited weaker associations that varied across time points and outcome definitions. Serial measurements over the first 24 h contributed incremental prognostic information; however, no dynamic index outperformed the baseline ALBI score in predictive strength.ConclusionALBI was consistently associated with TIC-related outcomes assessed 48 h after admission, and this association remained stable across the examined clinical subgroups. ALBI may serve as a readily available adjunctive risk marker for early coagulopathy risk stratification. Prospective validation is warranted before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "ongyang Hospital of Wenzhou Medical University, Dongyang/Jinhua, Zhejiang, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiejun Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinxin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiao Bao"
    },
    {
      "affs": [
        0
      ],
      "name": "Weichao Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Manzhen Ying"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4whd9ebgzjjk0.bib",
  "cited_by": 0,
  "doi": "10.3389/fsurg.2026.1860161",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fsurg.2026.1860161/full",
  "id": "4whd9ebgzjjk0",
  "issns": [
    "2296-875X"
  ],
  "landing_url": "https://doi.org/10.3389/fsurg.2026.1860161",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RD1-811"
    ],
    [
      "openalex",
      "2706|Trauma, Hemostasis, Coagulopathy, Resuscitation"
    ]
  ],
  "openalex": "W7223372384",
  "pdf_url": "https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2026.1860161/pdf",
  "pmcid": "PMC13741367",
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/4whd9ebgzjjk0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:05Z",
      "native_id": "4768f8adb5da4f8b8201392316c8101d",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fsurg.2026.1860161"
    },
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "PMC:PMC13741367",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13741367"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RD1-811",
      "subfield": "surgery"
    }
  ],
  "title": "Association of composite liver function indices with trauma-induced coagulopathy in adult trauma patients",
  "title_text": "Association of composite liver function indices with trauma-induced coagulopathy in adult trauma patients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/4whd9ebgzjjk0",
  "venue": "Frontiers in Surgery",
  "versions": []
}