{
  "abstract": "Background: A recently proposed estimated glomerular filtration rate (eGFR) slope-based criterion for clinical remission of chronic kidney disease (CKD) represents an emerging therapeutic paradigm. However, clinical courses meeting this criterion after sequential combination therapy with kidney-protective agents have rarely been reported in patients with type 2 diabetes mellitus (T2DM) and CKD. Case Presentation: A 70-year-old man with long-standing T2DM, nonproliferative diabetic retinopathy, and progressive albuminuric CKD presented in May 2023 with a urine albumin-to-creatinine ratio (UACR) of 121.60 mg/g creatinine (Cr), an eGFR of 28.00 mL/min/1.73 m2, hemoglobin A1c (HbA1c) of 7.5%, and serum potassium of 4.4 mmol/L. Kidney function had continued to decline despite treatment with a renin-angiotensin system inhibitor (RASi), a sodium-glucose cotransporter 2 inhibitor (SGLT2i), and insulin. Therapy was sequentially intensified with a glucagon-like peptide-1 receptor agonist (GLP-1RA) and finerenone, with close monitoring of kidney function and serum potassium. By January 2026, UACR had decreased to 26.53 mg/g Cr and eGFR had increased to 42.48 mL/min/1.73 m2. No adverse event required treatment discontinuation. Results: Ordinary least-squares regression of all 10 eGFR measurements yielded a positive slope that met the recently proposed eGFR slope-based criterion for clinical remission of CKD. Conclusions: In this patient with T2DM and CKD, the eGFR slope over the full follow-up met the proposed criterion for clinical remission of CKD during sequential multidrug kidney-protective therapy with safety monitoring. These observations require confirmation in prospective controlled studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tingting Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Liwei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shichun Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhihong Wang",
      "orcid": "0000-0003-3196-1739"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4x39aq377g6ws.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208149",
  "fulltext_url": null,
  "id": "4x39aq377g6ws",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8149",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ]
  ],
  "openalex": "W7223049462",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/4x39aq377g6ws.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15208149",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8149"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Chronic Kidney Disease and Diabetes",
      "subfield": "general"
    }
  ],
  "title": "Meeting a Proposed Estimated Glomerular Filtration Rate Slope-Based Criterion for Clinical Remission of Chronic Kidney Disease During Sequential Kidney-Protective Therapy in Type 2 Diabetes Mellitus: A Case Report",
  "title_text": "Meeting a Proposed Estimated Glomerular Filtration Rate Slope-Based Criterion for Clinical Remission of Chronic Kidney Disease During Sequential Kidney-Protective Therapy in Type 2 Diabetes Mellitus: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/4x39aq377g6ws",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}