{
  "abstract": "Late-stage labeling with fluorine-18 serves to advance clinical care and drug discovery via positron emission tomography (PET). This goal motivates efforts to expand the accessible chemical space with tailored 18F-containing groups. Sulfamoyl fluorides are promising because of their potential physiological stability. Existing synthetic routes largely depend on group-transfer protocols from preformed fluorosulfonyl reagents. As a result, synthetic methods for [18F]­sulfamoyl fluorides are fundamentally based on isotope exchange. None of the methods have enabled a no-carrier-added (NCA) protocol for radiofluorosulfonylation of amines. Herein, we provide nitrogen-centered radical-mediated assembling fluorosulfonylation reactions, enabling conversion of abundant NH-containing substrates into sulfamoyl fluorides with [19F]­fluoride and [18F]­fluoride as an exclusive fluorine source. Our method features high functional group tolerance, broad NH-substrates, and an NCA radiochemical technique. The initial preclinical evaluation of the freshly synthesized [18F]­SUFA-flurpiridaz and its in vivo myocardial perfusion PET imaging collectively highlights the potential physiological stability of sulfamoyl [18F]­fluoride groups and the potential application of our radical radiofluorosulfonylation strategy.",
  "abstract_shown": true,
  "affiliations": [
    "Hubei Research Center of Fundamental Science-Chemistry, Engineering Research Center of Organosilicon Compounds and Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China",
    "Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China",
    "Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China",
    "Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China",
    "Wuhan HTA Pharmaceutical Company Ltd., Wuhan 430075, China",
    "The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China",
    "Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juanjuan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiwei Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhiwei Xiao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yong He",
      "orcid": "0000-0002-9846-7578"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yongkang Gai",
      "orcid": "0000-0001-6766-5240"
    },
    {
      "affs": [
        1
      ],
      "name": "Dan Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Kui Xu"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhiqing Su"
    },
    {
      "affs": [
        5
      ],
      "name": "Xiao Shen",
      "orcid": "0000-0002-8675-1213"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Qiang Cheng",
      "orcid": "0000-0003-3877-1102"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4x732qcw2vm9b.bib",
  "cited_by": 0,
  "doi": "10.1021/acscentsci.6c00992",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720925/?tool=EBI",
  "id": "4x732qcw2vm9b",
  "issns": [
    "2374-7943",
    "2374-7951"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13720925",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W7213456213",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720925/pdf/?tool=EBI",
  "pmcid": "PMC13720925",
  "pmid": "42964602",
  "published": "2026-09-17",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/4x732qcw2vm9b.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13720925",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720925"
    },
    {
      "first_seen": "2026-11-03T12:21:43Z",
      "native_id": "PMC13720925",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acscentsci.6c00992"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiopharmaceutical Chemistry and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Late-Stage Radical (Radio)fluorosulfonylation of Amines with [19F]fluoride and [18F]fluoride",
  "title_text": "Late-Stage Radical (Radio)fluorosulfonylation of Amines with [19F]fluoride and [18F]fluoride",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:43Z",
  "url": "https://research.draconitic.com/paper/4x732qcw2vm9b",
  "venue": "ACS central science",
  "versions": []
}