{
  "abstract": "Introduction\n\nHuman metapneumovirus (HMPV) is a common cause of acute respiratory tract infections (ARTIs) in children. This study characterized the epidemiological patterns of pediatric HMPV infection in Tianjin from 2012 to 2024 and analyzed the genetic features of circulating strains to inform prevention and control strategies.Methods\n\nEpidemiological data collected from 2012 to 2024 were retrospectively analyzed to describe the seasonality and age distribution of pediatric HMPV infection. Novel primers were designed for whole-genome sequencing, and circulating HMPV strains were characterized by subtype, recombination signals, amino acid substitutions, and glycosylation sites.Results\n\nPediatric HMPV infection in Tianjin showed seasonal and age-related patterns. The dominant type alternated between HMPV-A and HMPV-B every 1-3 years. Four major subtypes, A2b, A2c, B1, and B2, were detected, and A2c predominated in recent years. Genetic and molecular analyses identified recombination signals in several sequences, as well as amino acid substitutions and glycosylation sites.Conclusion\n\nThis study characterized the epidemiological patterns of pediatric HMPV infection in Tianjin from 2012 to 2024. The newly designed primers supported whole-genome sequencing and analyses of viral genetic variation and recombination. These findings provide epidemiological and genomic evidence to inform HMPV prevention and control.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Microbiology, Tianjin Centers for Disease Control and Prevention, Tianjin, China.",
    "Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease, Tianjin Centers for Disease Control and Prevention, Tianjin, China.",
    "Caofeidian District Center for Disease Control and Prevention, Tangshan City, Hebei Province, China.",
    "Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mingkun Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Rui Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Liru Guo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mei Kong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Peng Zhang"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Xiaoyan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4xtwq55x70ctj.bib",
  "cited_by": 0,
  "doi": "10.46234/ccdcw2026.198",
  "fulltext_url": "https://europepmc.org/articles/PMC13673391",
  "id": "4xtwq55x70ctj",
  "issns": [
    "2096-7071"
  ],
  "landing_url": "https://europepmc.org/article/MED/42890514",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7216576392",
  "pdf_url": "https://europepmc.org/articles/PMC13673391?pdf=render",
  "pmcid": "PMC13673391",
  "pmid": "42890514",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4xtwq55x70ctj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42890514",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42890514"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Epidemiological and Genetic Characterization of Human Metapneumovirus in Children - Tianjin, China, 2012-2024.",
  "title_text": "Epidemiological and Genetic Characterization of Human Metapneumovirus in Children - Tianjin, China, 2012-2024.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/4xtwq55x70ctj",
  "venue": "China CDC weekly",
  "versions": []
}