{
  "abstract": "ObjectiveThis systematic review and meta-analysis of randomized controlled trials aims to analyze the efficacy of mindfulness-based interventions and biofeedback on headache frequency, pain intensity, headache-related disability, psychological distress, and quality of life in adult patients with migraine.MethodsThe review followed the PRISMA statement and was registered in PROSPERO (CRD420261381587). A structured search was conducted across PubMed, Scopus, and PsycInfo for RCTs published in English between May 2016 and May 2026. Seven clinical trials (n = 535 participants) met the inclusion criteria. Methodological quality and risk of bias were evaluated using the Cochrane Risk of Bias 2 (RoB 2) tool.ResultsThe pooled analysis for headache frequency (n = 6 studies) showed no statistically significant differences between groups (MD = −0.59; 95% CI: −1.81 to 0.62; p = 0.34). Conversely, significant improvements favoring the experimental groups were found for headache-related disability measured with the HIT-6 scale (n = 6 studies; MD = −2.28; 95% CI: −4.47 to −0.08; p = 0.04), pain intensity (n = 3 studies; SMD = −0.39; 95% CI: −0.64 to −0.14; p = 0.002), and health-related quality of life (n = 3 studies; MD = +5.21; 95% CI: 1.95 to 8.47; p = 0.002). No statistically significant differences were observed for anxiety (p = 0.30) or depression (p = 0.88).ConclusionInterventions incorporating Mindfulness-Based Interventions and Biofeedback do not significantly reduce objective migraine attack frequency compared to control conditions, nor do they yield distinct differences in affective outcomes (anxiety/depression)—which may partly reflect subclinical baseline depression scores in episodic cohorts, active-comparator effects, and instrument heterogeneity. However, they exhibit statistically significant efficacy in decreasing subjective pain intensity, mitigating headache-related functional disability, and restoring health-related quality of life, supporting their role as valuable complementary strategies for self-regulation and clinical coping in migraine management.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420261381587, Identifier: CRD420261381587.",
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  "author_total": 7,
  "authors": [
    {
      "name": "Chaimae Zahri-Haidar"
    },
    {
      "name": "Jose I. Recio-Rodriguez"
    },
    {
      "name": "Natalia Sanchez-Aguadero"
    },
    {
      "name": "Hsin-Chien Lee"
    },
    {
      "name": "Luis López-Mesonero"
    },
    {
      "name": "Hsueh-Chen Lu"
    },
    {
      "name": "Irene A. Garcia-Yu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4y5a98r0w8zyh.bib",
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  "doi": "10.3389/fnins.2026.1965907",
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  "language": "en",
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  "published": "2026-11-11",
  "publisher": "Frontiers Media SA",
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  "subjects": [
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  "title": "Efficacy of mindfulness-based interventions and biofeedback for migraine management: a systematic review and meta-analysis of randomized controlled trials",
  "title_text": "Efficacy of mindfulness-based interventions and biofeedback for migraine management: a systematic review and meta-analysis of randomized controlled trials",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T15:20:27Z",
  "url": "https://research.draconitic.com/paper/4y5a98r0w8zyh",
  "venue": "Frontiers in Neuroscience",
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