{
  "abstract": "Plants in natural environments often encounter multifactorial abiotic stress combinations that trigger regulatory responses distinct from those triggered by individual stresses. Traditional single-stress paradigms inadequately capture these complex interactions, limiting crop improvement efforts. Here, we discuss how plants integrate conserved signaling pathways with combination-specific regulatory modules (CSRMs) across multiple regulatory layers to mediate stress tolerance. Using recent findings, including the identification of specific transcription factor complexes that decode unique stress combinations, we highlight how CSRMs coordinate downstream protective pathways such as reactive oxygen species buffering. These insights suggest a multi-layered regulatory logic underlying plant adaptation to combined stresses. Leveraging CSRMs through integrative discovery and engineering approaches offers a promising avenue for developing climate-smart crops with potentially enhanced and stable tolerance under unpredictable field conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Guangdong Key Laboratory of Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China",
    "Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Guangdong Technology Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China",
    "Department of Plant Breeding, Swedish University of Agricultural Sciences, Alnarp, Sweden",
    "Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, QLD, 4072, Australia",
    "VinUni Big Data Institute VinUniversity, Hanoi, Vietnam",
    "Hunan University of Arts and Science, Hunan Innovation Center for Synthetic Biomanufacturing Industry, Changde 415000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ali Raza",
      "orcid": "0000-0002-5120-2791"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yiran Li",
      "orcid": "0000-0003-1252-1842"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mengkai Zhao",
      "orcid": "0000-0002-7647-3520"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tao Ming"
    },
    {
      "affs": [
        2
      ],
      "name": "Rodomiro Octavio Ortiz",
      "orcid": "0000-0002-1739-7206"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Robert James Henry",
      "orcid": "0000-0002-4060-0292"
    },
    {
      "affs": [
        0,
        5,
        1
      ],
      "name": "Zhangli Hu",
      "orcid": "0000-0002-2596-8515"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4y6c1n6s1yf81.bib",
  "cited_by": 5,
  "doi": "10.1016/j.stress.2026.101458",
  "fulltext_url": null,
  "id": "4y6c1n6s1yf81",
  "issns": [
    "2667-064X"
  ],
  "landing_url": "https://doi.org/10.1016/j.stress.2026.101458",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Stress Responses and Tolerance"
    ]
  ],
  "openalex": "W7166205127",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-26",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/4y6c1n6s1yf81.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:50Z",
      "native_id": "W7166205127",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.stress.2026.101458"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Stress Responses and Tolerance",
      "subfield": "plant-biology"
    }
  ],
  "title": "Distinct regulatory networks mediate plant adaptation to multifactorial abiotic stress combinations: rethinking of plant stress genetics",
  "title_text": "Distinct regulatory networks mediate plant adaptation to multifactorial abiotic stress combinations: rethinking of plant stress genetics",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:09Z",
  "url": "https://research.draconitic.com/paper/4y6c1n6s1yf81",
  "venue": "Plant Stress",
  "versions": []
}