{
  "abstract": "Objective of the study: to evaluate the clinical effectiveness of complex non-pharmacological anti-stress therapy used as monotherapy and in combination with the herbal complex Tazalok in women with hypomenstrual syndrome, based on a comprehensive assessment of changes in menstrual function, ultrasonographic characteristics of the pelvic organs, quality-of-life indicators and laboratory evaluation of the hormonal profile over a six-month follow-up period. Materials and methods. The study included 100 women aged 18–40 years with hypomenstrual syndrome who were divided into two groups of 50 patients each. Women in Group I received non-pharmacological therapy for 6 months, including psychological support, lifestyle modification, nutritional correction, and optimization of physical activity. Patients in Group II additionally received Tazalok at a dose of 45 drops twice daily for 6 months. Clinical and ultrasound assessments were performed at baseline and after 1, 3, and 6 months of treatment. Serum levels of follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin, and cortisol were assessed, while quality of life was evaluated using the SF-36 questionnaire. Results. After 6 months of treatment, menstrual function was restored in 84% of patients in Group II compared with 70% in Group I. A regular menstrual cycle was observed in 78% and 52% of women, respectively (p < 0.05). According to ultrasound monitoring, ovulatory cycles after 6 months were detected in 60% of patients in Group II and 42% in Group I; however, the between-group difference did not reach statistical significance (p > 0.05). In contrast, laboratory-confirmed restoration of ovulation based on serum progesterone levels was observed in 68% of women in Group II versus 40% in Group I (p < 0.05). Patients who additionally received Tazalok demonstrated more pronounced positive changes in follicle-stimulating hormone, luteinizing hormone, estradiol, and progesterone levels, as well as a reduction in cortisol concentration. At 6 months, all assessed SF-36 domain scores were significantly higher in Group II compared with Group I (p < 0.05). Conclusions. The use of complex phytotherapy with anti-stress, anti-inflammatory, and hormone-modulating effects in combination with psychological counseling in women of reproductive age with hypomenstrual syndrome contributed to a faster and more complete restoration of menstrual and ovulatory function, favorable changes in the hormonal profile, and improvement in the physical, psycho-emotional, and social components of quality of life compared with non-pharmacological therapy alone. These findings indicate a comprehensive effect of Tazalok on the clinical and neuroendocrine manifestations of hypomenstrual syndrome and support its use as a component of complex therapy.",
  "abstract_shown": true,
  "affiliations": [
    "SI «Ukrainian Center of Motherhood and Childhood of the NAMS of Ukraine»; SSI «Center of Innovative Medical Technologies of the NAS of Ukraine», Kyiv, Ukraine",
    "SSI «Center of Innovative Medical Technologies of the NAS of Ukraine»; SI «Ukrainian Center of Motherhood and Childhood of the NAMS of Ukraine», Kyiv, Ukraine",
    "SI «Ukrainian Center of Motherhood and Childhood of the NAMS of Ukraine»; SI «Heart Institute of the Ministry of Health of Ukraine», Kyiv, Ukraine",
    "SI “Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine”, Kyiv, Ukraine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T.F. Tatarchuk",
      "orcid": "0000-0002-5498-4143"
    },
    {
      "affs": [
        1
      ],
      "name": "N.V. Kosei",
      "orcid": "0000-0003-3085-3285"
    },
    {
      "affs": [
        1
      ],
      "name": "S.I. Regeda",
      "orcid": "0000-0002-4960-7175"
    },
    {
      "affs": [
        0
      ],
      "name": "T.M. Tutchenko",
      "orcid": "0000-0002-3003-3650"
    },
    {
      "affs": [
        2
      ],
      "name": "T.E. Krysenko",
      "orcid": "0009-0003-1934-3687"
    },
    {
      "affs": [
        3
      ],
      "name": "H.A. Hordiienko",
      "orcid": "0000-0001-9430-7588"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4yathxgb1tgtx.bib",
  "cited_by": 0,
  "doi": "10.18370/2309-4117.2026.85.25-36",
  "fulltext_url": "https://reproduct-endo.com/article/view/377801",
  "id": "4yathxgb1tgtx",
  "issns": [
    "2309-4117",
    "2411-1295"
  ],
  "landing_url": "https://doi.org/10.18370/2309-4117.2026.85.25-36",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RG1-991"
    ],
    [
      "openalex",
      "2739|Menstrual Health and Disorders"
    ]
  ],
  "openalex": "W7223572722",
  "pdf_url": "https://reproduct-endo.com/article/download/377801/360356",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Publishing House TRILIST",
  "ris": "https://research.draconitic.com/paper/4yathxgb1tgtx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:44Z",
      "native_id": "43135dc47025480e947b54451b6b328a",
      "source": "doaj",
      "url": "https://doi.org/10.18370/2309-4117.2026.85.25-36"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Menstrual Health and Disorders",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Hypomenstrual disorders associated with chronic stress: non-hormonal treatment options",
  "title_text": "Hypomenstrual disorders associated with chronic stress: non-hormonal treatment options",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:44Z",
  "url": "https://research.draconitic.com/paper/4yathxgb1tgtx",
  "venue": "Репродуктивная эндокринология",
  "versions": []
}