{
  "abstract": "Background\n\nGa-68 prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) improves lesion detection in patients with biochemical recurrence (BCR) of prostate cancer. However, real-world evidence linking imaging-driven management changes to early biochemical outcomes remains limited, particularly in Korean populations. This study aimed to evaluate the impact of Ga-68 PSMA PET/CT on clinical management and its association with early biochemical response.Methods\n\nThis study included retrospectively registered 75 patients who underwent Ga-68 PSMA PET/CT for suspected BCR after radical prostatectomy between September 2022 and February 2024. Intended management at referral and final management after PET were compared. Biochemical outcomes were assessed based on follow-up prostate-specific antigen (PSA) levels.Results\n\nSeventy-five patients were analyzed (median age, 71 years; median PSA level, 0.30 ng/mL). PSMA PET/CT demonstrated positive findings in 28 patients (37.3%), including equivocal finding. Overall, intended management was changed in 19 patients (25.3%) following PET/CT. At after 2 years of follow-up, 49 patients achieved PSA ≤ 0.20 ng/mL, and 36 achieved PSA ≤ 0.03 ng/mL.Conclusions\n\nIn prostate cancer patients with suspected BCR, Ga-68 PSMA PET/CT led to clinically meaningful changes in management and influenced treatment selection in a Korean cohort. Larger prospective studies are warranted to further define its incremental clinical value.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nuclear Medicine, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.",
    "Proton Therapy Center, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea.",
    "Center for Urologic Cancer, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.",
    "Department of Urology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.",
    "Center for Urologic Cancer, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. urojy@ncc.re.kr.",
    "Department of Nuclear Medicine, National Cancer Center, 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea. skkim9nm@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sohyun Park"
    },
    {
      "affs": [
        0
      ],
      "name": "Tae-Sung Kim"
    },
    {
      "affs": [
        1
      ],
      "name": "Sung Uk Lee"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Nhu Quang Tran"
    },
    {
      "affs": [
        4
      ],
      "name": "Jae Young Joung"
    },
    {
      "affs": [
        5
      ],
      "name": "Seok-Ki Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4yfs622d3wcbb.bib",
  "cited_by": 0,
  "doi": "10.1186/s40644-026-01095-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13685158",
  "id": "4yfs622d3wcbb",
  "issns": [
    "1740-5025",
    "1470-7330"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908003",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R895-920"
    ],
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2740|Prostate Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7170841178",
  "pdf_url": "https://europepmc.org/articles/PMC13685158?pdf=render",
  "pmcid": "PMC13685158",
  "pmid": "42908003",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/4yfs622d3wcbb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42908003",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908003"
    },
    {
      "first_seen": "2026-10-30T13:46:20Z",
      "native_id": "4524cc66af8748898645aa7e08d0fcba",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s40644-026-01095-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    },
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "Clinical impact of PSMA PET/CT on the management of biochemical recurrence in prostate cancer.",
  "title_text": "Clinical impact of PSMA PET/CT on the management of biochemical recurrence in prostate cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:20Z",
  "url": "https://research.draconitic.com/paper/4yfs622d3wcbb",
  "venue": "Cancer imaging : the official publication of the International Cancer Imaging Society",
  "versions": []
}