{
  "abstract": "C-Glycoside analogs of bioactive glycans and glycoconjugates are resistant to glycosidic hydrolysis and thus represent valuable scaffolds for drug discovery and chemical biology. We previously found that CH2-linked isomaltose (CH2-IM) exhibits potent amylase-inducing activity in Aspergillus nidulans compared to its native and linkage-edited counterparts. Here, we report a streamlined synthesis of CH2-IM via photoredox-catalyzed vinyl-C-glycosylation using N,N-dialkylbenzylamine derivatives as efficient halogen-atom transfer reagents. This approach enables concise access to CH2-IM and also facilitates the synthesis of 6′-modified analogs, providing a versatile platform for probing structure–activity relationships of IM derivatives. Notably, functionalization at the 6′- and anomeric positions completely abolishes the amylase induction activity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Riko Tanabe"
    },
    {
      "name": "Makoto Yoritate"
    },
    {
      "name": "Minori Numamoto"
    },
    {
      "name": "Li Rui"
    },
    {
      "name": "Takahiro Moriyama"
    },
    {
      "name": "Noriaki Kiya"
    },
    {
      "name": "Hiroaki Matoba"
    },
    {
      "name": "Naoki Kato"
    },
    {
      "name": "Go Hirai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4yjynp24ye9b0.bib",
  "cited_by": 0,
  "doi": "10.1248/cpb.c26-00382",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00382/_article",
  "id": "4yjynp24ye9b0",
  "issns": [
    "1347-5223",
    "0009-2363"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00382/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/medicinal"
    ],
    [
      "openalex",
      "1605|Carbohydrate Chemistry and Synthesis"
    ]
  ],
  "openalex": "W7204250115",
  "pdf_url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00382/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4yjynp24ye9b0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1248/cpb.c26-00382",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00382/_article"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Carbohydrate Chemistry and Synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Synthesis of CH₂-Linked Isomaltose via α-Selective Photoredox Vinyl C-Glycosylation",
  "title_text": "Synthesis of CH₂-Linked Isomaltose via α-Selective Photoredox Vinyl C-Glycosylation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/4yjynp24ye9b0",
  "venue": "Chemical and Pharmaceutical Bulletin",
  "versions": []
}