{
  "abstract": "Background: Cervical intraepithelial neoplasia grade 1 (CIN1) is generally managed by observation because spontaneous regression is common and progression to high-grade disease is uncommon. Nevertheless, some patients with persistent HPV infection or repeated low-grade abnormalities may elect active treatment after appropriate counseling. This study aimed to describe the clinical outcomes and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in patients with CIN1 who underwent active treatment.\n\nMethods: This retrospective cohort study included 269 patients with CIN1 who underwent ALA-PDT at Peking University Shenzhen Hospital between July 2021 and July 2025. All patients received six sessions of ALA-PDT at intervals of 7–14 days. HPV status and ThinPrep cytologic test (TCT) results were assessed before treatment and during follow-up at 3 months (± 1 month) and, in some patients, at 6 months (± 1 month) after treatment. HPV clearance, cytological improvement, and treatment-related adverse events were analyzed.\n\nResults: Among the 266 HPV-positive patients, 155 patients (58.27%) had a negative HPV result at the predefined 3-month follow-up. At 3 months, 205 of 247 patients (83.00%) with available cytological assessment had NILM cytology. No serious adverse events were observed during treatment or follow-up.\n\nConclusions: In this retrospective cohort study, HPV negativity and improved cytological findings were observed during follow-up after ALA-PDT, together with an acceptable safety profile and no serious adverse events.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, Southern University of Science and Technology",
    "Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital",
    "Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases",
    "Cheeloo College of Medicine, Shandong University",
    "Department of Obstetrics and Gynecology, Shenzhen Shenshan People’s Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tianci Fan"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Lina Geng"
    },
    {
      "affs": [
        3
      ],
      "name": "Guanwen Gao"
    },
    {
      "affs": [
        4
      ],
      "name": "Zixun Long"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Degao Liu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yunfei Wang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Changzhong Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ykm1pzbvk6mv.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1896229",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730827/?tool=EBI",
  "id": "4ykm1pzbvk6mv",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1896229/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7223153027",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1896229/pdf",
  "pmcid": "PMC13730827",
  "pmid": "42979652",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4ykm1pzbvk6mv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1896229",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1896229/full"
    },
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13730827",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13730827"
    },
    {
      "first_seen": "2026-11-07T12:23:18Z",
      "native_id": "PMC13730827",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1896229"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Real-world clinical outcomes of 5-aminolevulinic acid photodynamic therapy in patients with cervical intraepithelial neoplasia grade 1",
  "title_text": "Real-world clinical outcomes of 5-aminolevulinic acid photodynamic therapy in patients with cervical intraepithelial neoplasia grade 1",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:18Z",
  "url": "https://research.draconitic.com/paper/4ykm1pzbvk6mv",
  "venue": "Frontiers in Oncology",
  "versions": []
}