{
  "abstract": "Introduction: To evaluate a configuration-specific inter-subject receive template as an alternative to participant-specific receive referencing within the evaluated 3 T scanner configuration.\n\nMethods: Datasets from twenty-five healthy subjects were analyzed using a strict leave-one-participant-out method. Each degree-3 template used the other 24 participants. Arm E used a participant-specific effective relative receive divisor; Arm T used the held-out template. Both arms underwent independent, identically defined residual calibration, including a local intercept (C ₀ ), its spatially regularized field (μ), and the mean-normalized form used downstream (μ). This was followed by ventricular-CSF calibration. Primary outcomes were participant-level median quantitative water content (qWC) in white and gray matter; whole brain was secondary. Paired bias, mean absolute error (MAE), Bland–Altman limits, Pearson r, and Lin concordance correlation coefficient (CCC) were calculated.\n\nResults: Mean relative receive-template mismatch was 2.273% (standard deviation (SD), 0.568%; range, 1.431%–3.615%). Mean Arm T minus Arm E differences were −0.04 percentage units (p.u.; dimensionless water fraction relative to pure water = 100 p.u.) in white matter and −0.17 p.u. in gray matter; MAE was 0.17 and 0.22 p.u., and CCC was 0.991 and 0.989, respectively. Whole-brain bias was −0.12 p.u. (MAE, 0.19 p.u.; CCC, 0.993). Bland–Altman widths were below 1 p.u. Exploratory associations between global mismatch and qWC disagreement were weak; all 95% participant-bootstrap confidence intervals spanned zero.\n\nDiscussion: Under symmetric arm-specific calibration, the configuration-specific template produced qWC estimates in close agreement with the participant-specific explicit reference strategy. This internal matched-configuration result supports technical feasibility but does not establish formal equivalence, interchangeability, or external generalization.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jülich",
    "Department of Neurology, RWTH Aachen University",
    "JARA–BRAIN – Translational Medicine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
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        0
      ],
      "name": "Zaheer Abbas"
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    {
      "affs": [
        0
      ],
      "name": "Faizan Ullah"
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    {
      "affs": [
        0
      ],
      "name": "Sergo Gegechkori"
    },
    {
      "affs": [
        0
      ],
      "name": "Wieland A. Worthoff"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "N. Jon Shah"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ypetbk5mdph6.bib",
  "cited_by": 0,
  "doi": "10.3389/fnins.2026.1986813",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724431/?tool=EBI",
  "id": "4ypetbk5mdph6",
  "issns": [
    "1662-453X",
    "1662-4548"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fnins.2026.1986813/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
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      "openalex",
      "2741|Advanced MRI Techniques and Applications"
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  "pdf_url": "https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1986813/pdf",
  "pmcid": "PMC13724431",
  "pmid": "42973491",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4ypetbk5mdph6.ris",
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    },
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  "subjects": [
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      "origin": "openalex:2741|Advanced MRI Techniques and Applications",
      "subfield": "imaging"
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  "title": "Inter-subject receive-template substitution for quantitative brain water content mapping at 3 T: a leave-one-out evaluation",
  "title_text": "Inter-subject receive-template substitution for quantitative brain water content mapping at 3 T: a leave-one-out evaluation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:55Z",
  "url": "https://research.draconitic.com/paper/4ypetbk5mdph6",
  "venue": "Frontiers in Neuroscience",
  "versions": []
}