{
  "abstract": "Gastric cancer (GC) has a poor prognosis. Chemotherapy causes severe systemic toxicity, and only a small subset of patients benefits from HER2/PD‑L1‑targeted therapies. Tricin (TRI), a natural flavonoid with anti‑GC activity, is limited by poor water solubility and low bioavailability. This study aimed to construct TRI‑loaded liposomes (TRI@Lips) to overcome these drawbacks and evaluate their antitumor performance. TRI@Lips were prepared by thin‑film hydration and characterized by DLS, FTIR, TEM, and release assays. Cytotoxicity, cellular uptake, in vivo tumor distribution, antitumor efficacy, and biosafety were examined using SGC‑7901/GSE‑1 cells, fluorescent tracers, and xenograft mice. TRI@Lips showed uniform spherical morphology (average size: 217.5 nm, PDI: 0.198, zeta potential: −8.84 mV), with 87.3% encapsulation efficiency, 9.2% drug loading, and 67.2% release at pH 5.0 within 72 h. The IC50 against SGC‑7901 cells was 3.4 µg/mL, with minimal toxicity to GSE‑1 cells. EPR‑mediated tumor accumulation was confirmed. In vivo, TRI@Lips reduced tumor weight to 0.3 g and Ki67‑positive rate to 11.6%, without major organ injury. TRI@Lips enhance TRI solubility, cellular uptake, and tumor accumulation, representing a low‑toxic passive‑targeting candidate for GC treatment.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Health Science Center Xi'an Jiaotong University Xi'an P. R. China",
    "School of Pharmacy Jilin Medical University Jilin P. R. China",
    "Department of Pathology Jilin People's Hospital Jilin P. R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Baiji Cui",
      "orcid": "0000-0001-5481-2993"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongmei Zhang",
      "orcid": "0009-0003-3940-8759"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Libo Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Tianyi Zhang",
      "orcid": "0000-0002-5353-1257"
    },
    {
      "affs": [
        0
      ],
      "name": "Zengjun Guo",
      "orcid": "0000-0003-3266-6280"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ywgxb1akf9ys.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71830",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714443/",
  "id": "4ywgxb1akf9ys",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://doi.org/10.1002/cbdv.71830",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7224132907",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbdv.71830",
  "pmcid": "PMC13714443",
  "pmid": "42947431",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4ywgxb1akf9ys.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:56Z",
      "native_id": "PMC13714443",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71830"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Tricin‐Loaded Liposomes as a Passive Targeting Nanodelivery System for Enhanced Gastric Cancer Therapy",
  "title_text": "Tricin‐Loaded Liposomes as a Passive Targeting Nanodelivery System for Enhanced Gastric Cancer Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:56Z",
  "url": "https://research.draconitic.com/paper/4ywgxb1akf9ys",
  "venue": "Chemistry & Biodiversity",
  "versions": []
}