{
  "abstract": "This review examines the critical intersection between lifestyle-associated hyperglycemia and aggressive thyroid carcinoma, with a particular focus on the role of aberrant thyroid-stimulating hormone (TSH) glycosylation. Chronic hyperglycemia, a characteristic of metabolic disorders such as type 2 diabetes, contributes to a pro-oxidative and pro-inflammatory tumor microenvironment. We propose that this metabolic stress enhances the hexosamine biosynthetic pathway, which may result in abnormal structural remodeling of TSH, specifically hypersialylation and increased N-glycan branching. We hypothesize that these altered TSH glycoforms dynamically interact with the TSH receptor. Due to their prolonged circulatory half-life, they may redirect canonical signaling toward sustained, atypical modulation of oncogenic networks, notably the PI3K/Akt/mTOR and MAPK pathways. These proposed signaling alterations could potentially contribute to tumor cell proliferation, epithelial-mesenchymal transition, immune evasion, and potential resistance to multimodal therapies in advanced thyroid carcinomas. These glycomic alterations may represent potential biomarker candidates; however, their diagnostic and prognostic utility remains clinically unvalidated. These findings provide a rationale for investigating whether metabolic regulation and glycosylation-targeted approaches could contribute to future strategies for overcoming treatment resistance in aggressive thyroid carcinomas.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University",
    "Department of Surgical Oncology, Dr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Dayananda Sagar University",
    "Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arya P. R."
    },
    {
      "affs": [
        0
      ],
      "name": "Mehta Vedant Kamal"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaushik Joshi"
    },
    {
      "affs": [
        0
      ],
      "name": "Chinmai Jagadish"
    },
    {
      "affs": [
        1
      ],
      "name": "Souwarna Jamadar"
    },
    {
      "affs": [
        2
      ],
      "name": "Prashant Tiwari"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4ywsy95h1g1t0.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1968674",
  "fulltext_url": null,
  "id": "4ywsy95h1g1t0",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1968674/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4ywsy95h1g1t0.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:42Z",
      "native_id": "10.3389/fonc.2026.1968674",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1968674/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Lifestyle-associated hyperglycemia and aberrant TSH glycoforms in aggressive thyroid carcinoma: glycosylation-mediated mechanisms in treatment resistance hyperglycemia, TSH glycoforms & thyroid cancer",
  "title_text": "Lifestyle-associated hyperglycemia and aberrant TSH glycoforms in aggressive thyroid carcinoma: glycosylation-mediated mechanisms in treatment resistance hyperglycemia, TSH glycoforms & thyroid cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:42Z",
  "url": "https://research.draconitic.com/paper/4ywsy95h1g1t0",
  "venue": "Frontiers in Oncology",
  "versions": []
}