{
  "abstract": "Doxorubicin (DOX)–induced cardiotoxicity remains a major therapeutic limitation, emerging at the intersection of oxidative stress, mitochondrial impairment, and disruption of survival signaling pathways. The Wnt/β‑catenin–GSK‑3β pathway is an essential regulator of cardiomyocyte survival. To assess the cardioprotective potential of nanocurcumin (N‐Cur) in this condition, twenty‐four Wistar rats were divided into four groups (N‐Cur; 80 mg/kg, oral) was given for 2 weeks, while DOX was administered on day seven as a single dose. N‐Cur treatment significantly standardized DOX‑induced elevations in cTnI and CK‑MB, restored cardiac antioxidants (GSH, SOD), decreased MDA levels with p ≤ 0.01, significantly restored Nrf2, and reduced pro‑inflammatory mediators (TNF‑α, IL‑6, NF‑κB‑p65) (p < 0.001), thereby augmenting its twin roles as a potent anti‐inflammatory and antioxidant agent. The histopathological changes and inflammatory infiltration caused by DOX were significantly diminished following N‐Cur treatment. Further, DOX inhibited Wnt/β‑catenin signaling and increased GSK‑3β expression, whereas N‐Cur reversed these changes in immunohistochemistry studies. Collectively, these findings indicate that N‐Cur provides significant cardiomyocyte protection and efficiently modifies the Wnt/β‑catenin–GSK‑3β axis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anatomy, College of Medicine King Saud University Riyadh Saudi Arabia",
    "Department of Pharmacology and Toxicology, College of Pharmacy King Saud University Riyadh Saudi Arabia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Noha A. Alshuwayer",
      "orcid": "0000-0003-3946-4999"
    },
    {
      "affs": [
        1
      ],
      "name": "Qamraa H. Alqahtani",
      "orcid": "0000-0002-6538-9710"
    },
    {
      "affs": [
        1
      ],
      "name": "Marwa H. Hussein"
    },
    {
      "affs": [
        0
      ],
      "name": "Raeesa Mohammed"
    },
    {
      "affs": [
        0
      ],
      "name": "Abdulaziz Siyal",
      "orcid": "0009-0004-2904-6333"
    },
    {
      "affs": [
        1
      ],
      "name": "Iman H. Hasan",
      "orcid": "0000-0001-7311-1412"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4z03meft3n1kz.bib",
  "cited_by": 0,
  "doi": "10.1002/jbt.71158",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734285/",
  "id": "4z03meft3n1kz",
  "issns": [
    "1095-6670",
    "1099-0461"
  ],
  "landing_url": "https://doi.org/10.1002/jbt.71158",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7225234084",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71158",
  "pmcid": "PMC13734285",
  "pmid": "42981109",
  "published": "2026-11-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/4z03meft3n1kz.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:54Z",
      "native_id": "PMC13734285",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jbt.71158"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Nanocurcumin Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating the Wnt/β‐Catenin/GSK‐3β Signaling Axis in Wistar Rats",
  "title_text": "Nanocurcumin Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating the Wnt/β‐Catenin/GSK‐3β Signaling Axis in Wistar Rats",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:54Z",
  "url": "https://research.draconitic.com/paper/4z03meft3n1kz",
  "venue": "Journal of Biochemical and Molecular Toxicology",
  "versions": []
}