{
  "abstract": "Mammalian heart regeneration is restricted to a brief postnatal period during which neonatal-specific mechanisms, including a tightly regulated immune response, enable tissue repair. Here, we show that cardiac injury during the regenerative window induces the accumulation of a distinct γδ T cell population that is absent from older, non-regenerative hearts. Following injury, these cells serve as a rapid source of IL-17A, which shapes the timing and composition of the neonatal immune response. Genetic ablation of γδ T cells or disruption of IL-17 signaling limits heart regeneration and results in dysregulated immune cell infiltration and impaired cardiac function. Mechanistically, our data suggest that γδ T cell-derived IL-17A acts on myeloid cells to initiate a rapid, self-limited inflammatory response that facilitates apoptotic cell clearance and limits sustained inflammation. Our study identifies a developmentally restricted immune axis that supports heart regeneration and advances our understanding of how neonatal-specific immune circuits shape tissue repair.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Stephanie Vargas Aguilar"
    },
    {
      "name": "Matthieu Dos Santos"
    },
    {
      "name": "Wei Tan"
    },
    {
      "name": "Efrain Sanchez-Ortiz"
    },
    {
      "name": "Kenian Chen"
    },
    {
      "name": "Hui Li"
    },
    {
      "name": "Lin Xu"
    },
    {
      "name": "Ning Liu",
      "orcid": "0000-0003-0257-1889"
    },
    {
      "name": "Eric N. Olson",
      "orcid": "0000-0003-1151-8262"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4z1cvfgah8bpa.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.118100",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714242/",
  "id": "4z1cvfgah8bpa",
  "issns": [
    "2211-1247"
  ],
  "landing_url": "https://linkinghub.elsevier.com/retrieve/pii/S2211124726011794",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Congenital heart defects research"
    ]
  ],
  "openalex": "W7220858851",
  "pdf_url": null,
  "pmcid": "PMC13714242",
  "pmid": "42842371",
  "published": "2026-10-01",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/4z1cvfgah8bpa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:34Z",
      "native_id": "10.1016/j.celrep.2026.118100",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2211124726011794"
    },
    {
      "first_seen": "2026-11-01T12:21:46Z",
      "native_id": "PMC13714242",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.celrep.2026.118100"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Congenital heart defects research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A developmentally restricted γδ T cell-IL-17A axis supports mouse heart regeneration",
  "title_text": "A developmentally restricted γδ T cell-IL-17A axis supports mouse heart regeneration",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:46Z",
  "url": "https://research.draconitic.com/paper/4z1cvfgah8bpa",
  "venue": "Cell Reports",
  "versions": []
}