{
  "abstract": "Nuciferine, a bioactive compound found in Nelumbo nucifera leaves, demonstrates diverse pharmacological activities, including anticancer effects. However, to our knowledge, no previous study has examined the effects of nuciferine on bladder cancer (BC). In this study, nuciferine was first isolated from locally sourced N. nucifera leaves and characterized using instrumental analysis. Signal transducer and activator of transcription 3 (STAT3), a potential anti-BC target, was identified through molecular docking analysis. In vivo assays demonstrated that nuciferine inhibited tumor growth in BC cell-based tumor-bearing mice. Nuciferine-treated mice showed an increase in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells and a decrease in Ki67-labeled cells. In addition, B-cell lymphoma 2 (Bcl-2) and STAT3 protein levels were reduced, whereas that of Bcl-2-associated X (Bax) was elevated following nuciferine treatment in mice. In conclusion, our findings suggest that nuciferine, a bioactive compound extracted from N. nucifera leaves, represents a potential candidate for preclinical treatment of BC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology Surgery, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University , ,",
    "Department of Pharmacy, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University , ,",
    "Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bin Qin"
    },
    {
      "affs": [
        1
      ],
      "name": "Hong Liang"
    },
    {
      "affs": [
        2
      ],
      "name": "Tongdong Kuang"
    },
    {
      "affs": [
        1
      ],
      "name": "Chaohe Wei"
    },
    {
      "affs": [
        2
      ],
      "name": "Meihui Qin"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiayao Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Huiling Lu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chao Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4z6rn5fwwzcqv.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1881388",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727535/?tool=EBI",
  "id": "4z6rn5fwwzcqv",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727535",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "1110|Medicinal Plant Research"
    ]
  ],
  "openalex": "W7223065486",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727535/pdf/?tool=EBI",
  "pmcid": "PMC13727535",
  "pmid": "42978773",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/4z6rn5fwwzcqv.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13727535",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727535"
    },
    {
      "first_seen": "2026-11-06T12:23:23Z",
      "native_id": "PMC13727535",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnut.2026.1881388"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Medicinal Plant Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Anti-bladder cancer effects of nuciferine, a bioactive compound extracted from Nelumbo nucifera leaves",
  "title_text": "Anti-bladder cancer effects of nuciferine, a bioactive compound extracted from Nelumbo nucifera leaves",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:42Z",
  "url": "https://research.draconitic.com/paper/4z6rn5fwwzcqv",
  "venue": "Frontiers in nutrition",
  "versions": []
}