{
  "abstract": "Meso oligoureas are dynamic hydrogen-bonded foldamers capable of reversible helix polarity inversion but have so far been limited to symmetrical meso-cyclohexane-1,2-diamine monomeric units, limiting both sequence diversity and structural modification. Here, we report the synthesis and characterization of meso and \"near-meso\" oligoureas assembled exclusively from chiral units, thereby expanding the accessible sequence space. Despite their overall symmetry, meso oligoureas display sequence-dependent helix-forming propensities. Controlled desymmetrization of terminal groups induces a preferred helix screw-sense, while binding of achiral hydrogen-bond acceptors reverses the directionality of the intramolecular hydrogen-bonding network, leading to sequence-dependent screw-sense inversion. Structural, spectroscopic, and solution studies consistently support this stimulus-responsive folding behavior.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Naveen Gupta"
    },
    {
      "name": "Mégane Bornerie"
    },
    {
      "name": "Bo Li"
    },
    {
      "name": "Antoine Hacihasanoglu"
    },
    {
      "name": "Orlando Villegas Bello"
    },
    {
      "name": "Stéphanie Antunes"
    },
    {
      "name": "Estelle Morvan"
    },
    {
      "name": "Jean‐marc Sotiropoulos"
    },
    {
      "name": "Philippe Carbonnière"
    },
    {
      "name": "Morgane Pasco"
    },
    {
      "name": "Brice Kauffmann"
    },
    {
      "name": "Céline Douat"
    },
    {
      "name": "Sung Hyun Yoo"
    },
    {
      "name": "Gilles Guichard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4z87gtn559239.bib",
  "cited_by": 0,
  "doi": "10.1002/anie.6601433",
  "fulltext_url": null,
  "id": "4z87gtn559239",
  "issns": [
    "1433-7851",
    "1521-3773"
  ],
  "landing_url": "https://hal.science/hal-05799032v1",
  "language": "en",
  "licence": "CC-BY-NC-SA-4.0",
  "licence_label": "CC BY-NC-SA 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "hal",
      "1.chim.theo"
    ],
    [
      "openalex",
      "1605|Supramolecular Chemistry and Complexes"
    ]
  ],
  "openalex": "W7220868239",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.6601433",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": "Wiley-VCH Verlag",
  "ris": "https://research.draconitic.com/paper/4z87gtn559239.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "hal-05799032",
      "source": "hal",
      "url": "https://hal.science/hal-05799032v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.theo",
      "subfield": "theoretical"
    }
  ],
  "title": "Control of Helix Screw‐Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units",
  "title_text": "Control of Helix Screw‐Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:49Z",
  "url": "https://research.draconitic.com/paper/4z87gtn559239",
  "venue": "Angewandte Chemie International Edition",
  "versions": []
}