{
  "abstract": "Objectives: To compare hepatic and splenic transverse relaxivity (R2*) derived from two-dimensional (2D) and three-dimensional (3D) multi-echo gradient-echo (ME-GRE) acquisitions before and after superparamagnetic iron oxide (SPIO) administration and to evaluate the effects of SPIO on proton density fat fraction (PDFF), MR spectroscopy (MRS)-derived PDFF, native T1 mapping, and magnetic resonance elastography (MRE)-derived liver stiffness. Materials and methods: In this retrospective study, 48 adults underwent liver MRI at 3 T before and after SPIO administration. Hepatic and splenic R2* and PDFF were obtained from 2D and 3D ME-GRE acquisitions processed using MRQuantif and LiverLab. MRS-derived PDFF, native variable flip angle T1 mapping, and MRE-derived liver stiffness were assessed before and after SPIO administration. Agreement between methods was evaluated using Pearson correlation coefficients, intraclass correlation coefficients (ICC), and Bland-Altman analysis. Predictors of SPIO-induced changes were assessed using multivariable linear regression. Results: SPIO administration resulted in a marked increase in hepatic R2* (approximately 3.5-fold), exceeding the increase observed in the spleen (approximately 2-fold), consistent with predominant hepatic uptake. Correlation between LiverLab and MRQuantif R2* measurements remained strong; however, inter-method agreement deteriorated at higher R2* values after SPIO administration. ME-GRE-based PDFF measurements remained stable with preserved inter-method agreement. In contrast, MRS-derived PDFF demonstrated reduced reliability after SPIO administration, with apparent increases in fat fraction and weakened correlation with ME-GRE PDFF measurements. Native hepatic T1 values decreased uniformly by approximately 500 ms following SPIO administration. MRE-derived liver stiffness showed no significant change after SPIO administration. Conclusion: Using SPIO as a controlled in vivo susceptibility model, this study provides an integrated evaluation of the susceptibility dependence of commonly used quantitative liver MRI biomarkers. SPIO-induced susceptibility effects substantially increase hepatic R2*, impair the reliability of MRS-based fat quantification, and markedly shorten native variable flip angle T1 measurements, while preserving the relative stability of ME-GRE-based PDFF and MRE-derived liver stiffness. These findings improve understanding of the susceptibility-related performance of quantitative liver MRI techniques and may help inform the interpretation and standardization of iron-sensitive MRI biomarkers.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Sami a Ba-Ssalamah"
    },
    {
      "name": "Sarah Poetter-Lang"
    },
    {
      "name": "Ahmet y Yitik"
    },
    {
      "name": "Tarik Abd El-Aal"
    },
    {
      "name": "Ahmed Ba-Ssalamah"
    },
    {
      "name": "Stephan Kannengiesser"
    },
    {
      "name": "Yves Gandon"
    },
    {
      "name": "Georg Langs"
    },
    {
      "name": "Nina Bastati"
    },
    {
      "name": "Ulrike Attenberger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4zkk0dt7yxjxn.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ejrad.2026.113116",
  "fulltext_url": null,
  "id": "4zkk0dt7yxjxn",
  "issns": [
    "0720-048X"
  ],
  "landing_url": "https://hal.science/hal-05753238v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "openalex",
      "2741|Advanced MRI Techniques and Applications"
    ]
  ],
  "openalex": "W7171240597",
  "pdf_url": "https://hal.science/hal-05753238/document",
  "pmcid": null,
  "pmid": "42537343",
  "published": "2026-07-25",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/4zkk0dt7yxjxn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:59Z",
      "native_id": "hal-05753238",
      "source": "hal",
      "url": "https://hal.science/hal-05753238v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "SPIO-induced susceptibility effects on quantitative liver MRI: cross-method assessment of R2*, PDFF, T1 mapping, and MRE",
  "title_text": "SPIO-induced susceptibility effects on quantitative liver MRI: cross-method assessment of R2*, PDFF, T1 mapping, and MRE",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:59Z",
  "url": "https://research.draconitic.com/paper/4zkk0dt7yxjxn",
  "venue": "European Journal of Radiology",
  "versions": []
}