{
  "abstract": "Background: Human adenovirus (HAdV) among pediatric allogeneic hematopoietic cell transplant (allo-HCT) recipients can result in asymptomatic infection with risk for disease progression. There are limited data defining HAdV infection, disease, and case-fatality rates in a HAdV polymerase chain reaction (PCR) surveillance testing era. The current study aimed to define these outcomes using a priori definitions applied by a central review committee.\n\nMethods: Pediatric allo-HCT recipients were followed up for 180 days after HCT at 10 pediatric institutions. Blood and stool specimens were collected 0–7 days prior to allo-HCT for serum HAdV immunoglobulin G and stool HAdV PCR testing. Clinical data, including HAdV PCR testing results, informed central review committee–designated outcomes of HAdV infection, including DNAemia, disease, and deaths (case-fatality rate). Outcomes were reported by HAdV surveillance testing status and by pretransplant research specimen results.\n\nResults: The cohort included 819 allo-HCT recipients; 649 (79.2%) were under HAdV surveillance. The HAdV infection and DNAemia incidence among surveilled patients was 27.1% and 16.0%, respectively. The incidence of proven or probable HAdV disease was 10.9% for the cohort and, 12.6% for those under surveillance. The HAdV infection incidence was highest (13 of 25 [52.0%]) in patients with pre-HCT HAdV immunoglobulin G and stool PCR positivity. The attributable case-fatality rate for those with proven or probable disease was 13.5%.\n\nConclusions: HAdV infection and disease are common among pediatric allo-HCT recipients. HAdV disease is associated with a substantial HAdV-attributable mortality rate. Clinical trials assessing novel HAdV in pediatric allo-HCT recipients are needed. Pretransplant serology and stool PCR testing could identify high-risk patients for trial enrollment.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "Brian T Fisher",
      "orcid": "0000-0002-8224-4281"
    },
    {
      "name": "Jesse A Blumenstock",
      "orcid": "0000-0001-7185-0705"
    },
    {
      "name": "Craig L K Boge",
      "orcid": "0000-0002-9226-5529"
    },
    {
      "name": "Sydney Shuster"
    },
    {
      "name": "Alix E Seif",
      "orcid": "0000-0002-1799-2582"
    },
    {
      "name": "Michael Green"
    },
    {
      "name": "Marian G Michaels"
    },
    {
      "name": "Jessie L Alexander"
    },
    {
      "name": "Monica I Ardura"
    },
    {
      "name": "Jeffery J Auletta",
      "orcid": "0000-0002-1515-2141"
    },
    {
      "name": "Tamara P Miller",
      "orcid": "0000-0003-4250-5376"
    },
    {
      "name": "Diego R Hijano",
      "orcid": "0000-0002-2903-666X"
    },
    {
      "name": "William J Muller",
      "orcid": "0000-0001-7690-0695"
    },
    {
      "name": "Jennifer E Schuster",
      "orcid": "0000-0001-6365-566X"
    },
    {
      "name": "Abby M Green"
    },
    {
      "name": "Daniel E Dulek"
    },
    {
      "name": "Yun Li",
      "orcid": "0000-0001-8225-4554"
    },
    {
      "name": "Adriana E Kajon"
    },
    {
      "name": "Michael Grimley"
    },
    {
      "name": "Lara Danziger-Isakov",
      "orcid": "0000-0002-5691-5221"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4zpk1tfqv90jz.bib",
  "cited_by": 0,
  "doi": "10.1093/cid/ciag398",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715987/",
  "id": "4zpk1tfqv90jz",
  "issns": [
    "1058-4838",
    "1537-6591"
  ],
  "landing_url": "https://doi.org/10.1093/cid/ciag398",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00290"
    ],
    [
      "heading",
      "Immunocompromised Hosts"
    ],
    [
      "heading",
      "Major Article"
    ],
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7203820641",
  "pdf_url": null,
  "pmcid": "PMC13715987",
  "pmid": "42619328",
  "published": "2026-08-20",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/4zpk1tfqv90jz.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:09Z",
      "native_id": "PMC13715987",
      "source": "pmc",
      "url": "https://doi.org/10.1093/cid/ciag398"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Incidence and Outcomes of Human Adenovirus Infection and Disease in a Multicenter Cohort of Pediatric Allogeneic Hematopoietic Cell Transplant Recipients",
  "title_text": "Incidence and Outcomes of Human Adenovirus Infection and Disease in a Multicenter Cohort of Pediatric Allogeneic Hematopoietic Cell Transplant Recipients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:09Z",
  "url": "https://research.draconitic.com/paper/4zpk1tfqv90jz",
  "venue": "Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America",
  "versions": []
}