{
  "abstract": "The recently isolated aspercyclicins A and B from Aspergillus sp. LI2020F001 represent a chimeric scaffold derived from crosstalk of two biosynthetic pathways. These natural products display cytotoxicity against cancer cell lines and potently activate immunogenic cell death (ICD). Herein, we report methodology development for biomimetic [4+2] cycloadditions involving an in situ generated isobenzofuran (IBF) leading to the semisyntheses of aspercyclicins A and B from the fungal-derived natural product (+)-geodin.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Edgar S. Villa"
    },
    {
      "name": "James McNeely"
    },
    {
      "name": "Hanna R. Warinner"
    },
    {
      "name": "John A. Porco",
      "orcid": "0000-0002-2991-5680"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/4zvtv8a7ejzr2.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15011019/v1",
  "fulltext_url": null,
  "id": "4zvtv8a7ejzr2",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011019/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organic Chemistry Synthesis Methods"
    ]
  ],
  "openalex": "W7223672017",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/4zvtv8a7ejzr2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15011019",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011019/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organic Chemistry Synthesis Methods",
      "subfield": "organic"
    }
  ],
  "title": "Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition",
  "title_text": "Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/4zvtv8a7ejzr2",
  "venue": "ChemRxiv",
  "versions": []
}