{
  "abstract": "The histone variant H2A.Z plays a critical role in the modulation of environmental responses, but the mechanisms regulating H2A.Z dynamics in response to stresses remain poorly understood in plants. Here we identify the ubiquitin carboxyl-terminal hydrolase UCH2 as a Pi-responsive chromatin regulator that promotes Pi starvation-induced (PSI) gene activation. We show that PHR1 recruits UCH2 to PSI gene promoters under Pi deficiency, where UCH2 deubiquitinates H2A.Z and promotes reduction in H2A.Z occupancy at PSI gene promoters. Loss of UCH2 impairs this reduction in H2A.Z occupancy, represses PSI gene induction, and reduces Pi accumulation. A catalytically inactive UCH2 mutant fails to complement these defects, and ubiquitination-deficient H2A.Z variants render plants insensitive to UCH2 loss. Our findings establish UCH2 as a critical chromatin regulator linking Pi sensing with H2A.Z dynamics and provide insights into how plants integrate chromatin-based regulation to maintain Pi homeostasis.",
  "abstract_shown": true,
  "affiliations": [
    "College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China.",
    "Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.",
    "University of Chinese Academy of Sciences, Beijing, China.",
    "State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.",
    "Genome Informatics Facility, Office of Biotechnology, Iowa State University, Ames, IA, USA.",
    "Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.",
    "College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. mglei@hznu.edu.cn."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Fanxiao Meng"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Xinlong Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Guojie Ma"
    },
    {
      "affs": [
        4
      ],
      "name": "Viswanathan Satheesh",
      "orcid": "0000-0002-8743-2847"
    },
    {
      "affs": [
        5
      ],
      "name": "Qigui Wu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yuhang Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianwei Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Junfeng Jiang"
    },
    {
      "affs": [
        6
      ],
      "name": "Mingguang Lei",
      "orcid": "0000-0002-6431-4530"
    },
    {
      "affs": [
        6
      ],
      "name": "Mingguang Lei",
      "orcid": "0000-0003-1382-7480"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/501p0kya770dy.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77882-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13680510",
  "id": "501p0kya770dy",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897203",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant Molecular Biology Research"
    ]
  ],
  "openalex": "W7213530763",
  "pdf_url": "https://europepmc.org/articles/PMC13680510?pdf=render",
  "pmcid": "PMC13680510",
  "pmid": "42897203",
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/501p0kya770dy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897203",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897203"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Molecular Biology Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "A ubiquitin carboxyl-terminal hydrolase facilitates H2A.Z removal in response to phosphate starvation.",
  "title_text": "A ubiquitin carboxyl-terminal hydrolase facilitates H2A.Z removal in response to phosphate starvation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/501p0kya770dy",
  "venue": "Nature communications",
  "versions": []
}