{
  "abstract": "Polyendocrine metabolic ovarian syndrome (PMOS) and type 2 diabetes milletus (T2DM) are interlinked endocrine and metabolic disorders characterized by insulin resistance (IR), hyperinsulinemia and chronic low-grade inflammation. Both these abnormal physiological and metabolic conditions share overlapping cellular and molecular pathways involving insulin signaling, PI3K/Akt dysregulation, oxidative stress (OS) and inflammatory cascades. In PMOS, these disturbances further intersect with reproductive axis dysfunction including hyperandrogenism and follicular arrest. This manuscript reviews the shared metabolic and reproductive signaling pathways in PMOS and T2DM, highlighting insulin signaling defects, AMPK–mTOR imbalance, WNT/β-catenin dysregulation and inflammatory mediators. Understanding these common pathways may facilitate development of unified and more specific therapeutic strategies targeting both metabolic and reproductive dysfunction among these disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology, Sher-i- Kashmir Institute of Medical Sciences",
    "Department of Biotechnology, Government Degree College (GDC) (Women)",
    "Department of Life Sciences, Jaipur National University, Jaipur",
    "Department of Allied and HealthCare, Guru Kashi University, Talwandi Sabo",
    "Department of Clinical Biochemistry, Government Degree College (GDC) (Women)"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Khurshid Ahmad Padder"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohd Ashraf Ganie"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Nusrat Jahan"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohmad Aadil Yousuf"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tajali Sehar"
    },
    {
      "affs": [
        1
      ],
      "name": "Mudasir Ahmad Bhat"
    },
    {
      "affs": [
        3
      ],
      "name": "Showkat Hussain"
    },
    {
      "affs": [
        1
      ],
      "name": "Saba Muzaffar"
    },
    {
      "affs": [
        1
      ],
      "name": "Sadiq Majeed"
    },
    {
      "affs": [
        1
      ],
      "name": "Refaz Ahmad Dar"
    },
    {
      "affs": [
        4
      ],
      "name": "Touseef Sheikh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/506mq73fmxw14.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1996827",
  "fulltext_url": null,
  "id": "506mq73fmxw14",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1996827/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Ovarian function and disorders"
    ]
  ],
  "openalex": "W7223035436",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1996827/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/506mq73fmxw14.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1996827",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1996827/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian function and disorders",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome",
  "title_text": "Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/506mq73fmxw14",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}