{
  "abstract": "Introduction: The present study aims to investigate the possible computerized cardiotocography (cCTG) parameter alteration in patients with elevated antenatal depressive symptoms, evaluated in the third trimester of pregnancy through the Edinburgh Postnatal Depression Scale (EPDS). Methods: We conducted a prospective observational study from 1 August 2024 to 20 August 2025. All pregnant women (after 30 gestational weeks) were included and underwent cCTG and the Edinburgh Postnatal Depression Scale (EPDS) evaluation. Based on their EPDS scores, pregnant women were divided into low (score < 10) or high depressive symptom (score ≥ 10) groups. For all included pregnant women, demographic characteristics and cCTG parameters were recorded. The baseline characteristics and cCTG parameters were compared between groups. Short-term variation (STV) difference represented the primary outcomes. Results: A total of 205 pregnant women were enrolled (median gestational age was 38.1 weeks). Demographic, obstetric, or fetal characteristics were homogenous between the groups. There were no cCTG parameter differences between high- and low-EPDS groups: baseline fetal heart rate (p = 0.743), short-term variability (p = 0.663), long-term variability (p = 0.550), accelerations (p = 0.893), and fetal movements (p = 0.275). The Hodges–Lehmann difference in STV was 0.20 ms (95% CI −0.60 to 1.00), and with excluded differences larger than ±1 ms. EPDS score and cCTG parameter correlations were weak (|ρ| ≤ 0.14). Discussion: Maternal depressive symptoms, in late gestation, were not associated with cCTG parameter alterations. These results excluded differences larger than 1 ms but additional studies are needed to explore the fetal autonomic changes related to the maternal depressive symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy",
    "Department of Psychiatry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy",
    "Department of Obstetrics and Gynecology, Ospedale S.G. Moscati, 83100 Avellino, Italy",
    "Medical Statistics Unit, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marco La Verde"
    },
    {
      "affs": [
        1
      ],
      "name": "Mario Luciano",
      "orcid": "0000-0002-4338-1371"
    },
    {
      "affs": [
        2
      ],
      "name": "Mario Ardovino",
      "orcid": "0009-0007-5414-7875"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Caparrotti"
    },
    {
      "affs": [
        0
      ],
      "name": "Franca Cerqua"
    },
    {
      "affs": [
        3
      ],
      "name": "Mario Fordellone",
      "orcid": "0000-0003-0790-892X"
    },
    {
      "affs": [
        1
      ],
      "name": "Bianca Della Rocca",
      "orcid": "0000-0003-0319-400X"
    },
    {
      "affs": [
        1
      ],
      "name": "Carlotta Brandi"
    },
    {
      "affs": [
        0
      ],
      "name": "Davide Pisani"
    },
    {
      "affs": [
        0
      ],
      "name": "Marco Torella",
      "orcid": "0000-0001-8853-5760"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/50fek2n2kv5qk.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218705",
  "fulltext_url": null,
  "id": "50fek2n2kv5qk",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8705",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/50fek2n2kv5qk.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218705",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8705"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Antenatal Depressive Symptoms and Computerized Cardiotocography Parameters: An Observational Prospective Study",
  "title_text": "Antenatal Depressive Symptoms and Computerized Cardiotocography Parameters: An Observational Prospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/50fek2n2kv5qk",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}