{
  "abstract": "Gravitational magnetic resonance elastography (GT‐MRE) enables comprehensive biomechanical liver characterization and may overcome limitations of conventional elastography techniques. This study evaluated the diagnostic performance of two‐ and three‐dimensional (2D and 3D) GT‐MRE compared with 2D acoustic MRE (AC‐MRE) and vibration‐controlled transient elastography (VCTE) for liver fibrosis staging. In this prospective study, patients with suspected or known steatotic liver disease underwent GT‐MRE (2D and 3D, gradient‐echo sequences) and AC‐MRE (2D, spin‐echo echo‐planar imaging) at 1.5 T, plus VCTE with a median interval to MRE of 37 days (IQR, 20–124 days; range, 0–372 days). Statistical analyses included generalized additive models, ordinal logistic regression, and decision tree‐based classification. Diagnostic performance was assessed using cumulative receiver operating characteristic analysis and corresponding areas under the curve (AUCs). Ninety‐one participants (median age, 55 years [IQR, 45–64]; 41 women) were included, of whom 35 (38%) had histopathological correlation. In the biopsy‐confirmed subgroup, 3D GT‐MRE‐derived viscoelastic parameters showed promising exploratory performance for early fibrosis classification. Wave attenuation achieved AUCs of 0.91 for F0 versus ≥ F1 and 0.99 for ≤ F1 versus ≥ F2, while phase angle yielded an AUC of 0.88 for F0 versus ≥ F1, with numerically higher AUCs than conventional stiffness‐based metrics. For advanced fibrosis thresholds, all modalities performed well (AUC ≥ 0.84). Obuchowski measures for 3D‐derived parameters were 0.95–0.96. Internally cross‐validated multiparametric modeling achieved an accuracy of up to 92%. VCTE measurements plateaued beyond F3, whereas AC‐ and GT‐MRE metrics continued to increase with fibrosis severity. 3D GT‐MRE‐derived viscoelastic parameters showed promising performance for liver fibrosis classification and provided biomechanical information complementary to conventional stiffness measurements. Given the limited biopsy‐confirmed sample and marked class imbalance at F0, these findings require validation in larger independent cohorts before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Goethe University Frankfurt, University Hospital Department of Radiology and Nuclear Medicine Frankfurt am Main Germany",
    "Goethe University Frankfurt, University Hospital Department of Pediatrics Frankfurt am Main Germany",
    "Goethe University Frankfurt, University Hospital Department of Internal Medicine I Frankfurt am Main Germany",
    "Goethe University Frankfurt, Faculty of Medicine Institute of Biostatistics and Mathematical Modeling Frankfurt am Main Germany",
    "Goethe University Frankfurt, University Hospital Department of Internal Medicine, Infectious Diseases Frankfurt am Main Germany",
    "University Hospital Jena, Institute of Diagnostic and Interventional Radiology, Section Neuroradiology Jena Germany",
    "Goethe University Frankfurt, University Hospital, Institute of Medical Virology Frankfurt am Main Germany",
    "Université de Paris, Center for Research on Inflammation, UMR 1149 National Institute for Health and Medical Research (INSERM), Team “From micro to macro in cancer development” Paris France",
    "King's College London School of Biomedical Engineering and Imaging Sciences London UK",
    "Goethe University Frankfurt, University Hospital Department of Cardiology and Angiology Frankfurt am Main Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Leon David Gruenewald",
      "orcid": "0000-0001-7959-5008"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Booz"
    },
    {
      "affs": [
        0
      ],
      "name": "Jennifer Gotta",
      "orcid": "0000-0002-0524-6574"
    },
    {
      "affs": [
        0
      ],
      "name": "Philipp Reschke",
      "orcid": "0009-0006-9123-7581"
    },
    {
      "affs": [
        0
      ],
      "name": "Tommaso D'Angelo",
      "orcid": "0000-0003-0004-6378"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicole Suarez Ziegengeist",
      "orcid": "0009-0006-2106-6043"
    },
    {
      "affs": [
        0
      ],
      "name": "Katerina Torgashov"
    },
    {
      "affs": [
        1
      ],
      "name": "Laura Hempfling",
      "orcid": "0009-0000-4558-6883"
    },
    {
      "affs": [
        0
      ],
      "name": "Scherwin Mahmoudi",
      "orcid": "0000-0002-4020-1873"
    },
    {
      "affs": [
        0
      ],
      "name": "Lisa Reisbeck",
      "orcid": "0009-0003-2301-6953"
    },
    {
      "affs": [
        0
      ],
      "name": "Renate Maria Hammerstingl"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Zeuzem"
    },
    {
      "affs": [
        2
      ],
      "name": "Esra Görgülü"
    },
    {
      "affs": [
        2
      ],
      "name": "Anita Pathil‐Warth"
    },
    {
      "affs": [
        2
      ],
      "name": "Melis Onay",
      "orcid": "0009-0008-3018-6359"
    },
    {
      "affs": [
        3
      ],
      "name": "Eva Herrmann",
      "orcid": "0000-0002-0662-6675"
    },
    {
      "affs": [
        3
      ],
      "name": "Iulia Dahmer",
      "orcid": "0009-0008-0125-1799"
    },
    {
      "affs": [
        4
      ],
      "name": "Raja Idris"
    },
    {
      "affs": [
        4
      ],
      "name": "Maria Johanna Gobertina Tetuanui Vehreschild"
    },
    {
      "affs": [
        5
      ],
      "name": "Katharina Schregel",
      "orcid": "0000-0003-4367-1667"
    },
    {
      "affs": [
        5
      ],
      "name": "Christof Matthias Sommer"
    },
    {
      "affs": [
        6
      ],
      "name": "Sandra Ciesek"
    },
    {
      "affs": [
        0
      ],
      "name": "Katrin Eichler"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Joseph Vogl"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Ralph Sinkus",
      "orcid": "0000-0002-6093-1654"
    },
    {
      "affs": [
        9
      ],
      "name": "Sebastian Haberkorn",
      "orcid": "0000-0003-3100-2167"
    },
    {
      "affs": [
        0
      ],
      "name": "Vitali Koch",
      "orcid": "0000-0001-6915-5906"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/51157r2qnyypv.bib",
  "cited_by": 0,
  "doi": "10.1002/nbm.70429",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731058/",
  "id": "51157r2qnyypv",
  "issns": [
    "0952-3480",
    "1099-1492"
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  "landing_url": "https://doi.org/10.1002/nbm.70429",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
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      "openalex",
      "2741|Ultrasound Imaging and Elastography"
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  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/nbm.70429",
  "pmcid": "PMC13731058",
  "pmid": "42977476",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/51157r2qnyypv.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:19Z",
      "native_id": "PMC13731058",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Ultrasound Imaging and Elastography",
      "subfield": "imaging"
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  ],
  "title": "Diagnostic Performance of Magnetic Resonance Elastography Versus Vibration‐Controlled Transient Elastography for Liver Fibrosis Staging in Steatotic Liver Disease",
  "title_text": "Diagnostic Performance of Magnetic Resonance Elastography Versus Vibration‐Controlled Transient Elastography for Liver Fibrosis Staging in Steatotic Liver Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:19Z",
  "url": "https://research.draconitic.com/paper/51157r2qnyypv",
  "venue": "Nmr in Biomedicine",
  "versions": []
}