{
  "abstract": "The liver possesses a remarkable regenerative capacity to restore tissue integrity and physiological function following acute injury. However, this endogenous repair potential is gradually impaired in chronic liver diseases, including metabolic dysfunction–associated steatohepatitis (MASH) and hepatic fibrosis. These disorders frequently lead to persistent inflammation and progressive hepatic dysfunction. Our incomplete understanding of the mechanisms behind pathological liver regeneration limits the development of new regenerative therapies. This review summarizes recent advances in liver regeneration across temporal, cellular, metabolic, and interorgan communication aspects. It describes the dynamic features of different regenerative phases and emphasizes the regulatory roles of non‐parenchymal cells within the regenerative niche. We also outline promising translational strategies, including molecular‐targeted therapy, cell‐based therapy, liver tissue engineering, and nanocarrier delivery systems. This review links basic mechanistic findings to clinical translation, discusses key existing research challenges, and offers useful insights for developing precision therapeutics for liver regeneration.",
  "abstract_shown": true,
  "affiliations": [
    "School of Future Medicine Beijing University of Chinese Medicine Beijing China",
    "State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Advanced Pharmaceuticals and Biomaterials China Pharmaceutical University Nanjing China",
    "Clinical Translational Science Center Beijing Tsinghua Changgung Hospital Tsinghua University Beijing China",
    "Department of Biomedical Engineering School of Biomedical Engineering Tsinghua University Beijing China",
    "Department of Hepatobiliary and Pancreatic Surgery General Surgery Center First Hospital of Jilin University Changchun China",
    "School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan China",
    "CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Mingyue Pan"
    },
    {
      "affs": [
        2
      ],
      "name": "Ni An"
    },
    {
      "affs": [
        3
      ],
      "name": "Yutian Feng"
    },
    {
      "affs": [
        4
      ],
      "name": "Yuelei Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chongqin Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxin Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuanzheng Huang"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Tanqing Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingru Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Pengfei Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaomeng Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenzhen Yin"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Zhiyuan Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoxuan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Liu",
      "orcid": "0000-0003-1399-6719"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/51ca8by9mpf6q.bib",
  "cited_by": 0,
  "doi": "10.1002/mco2.71108",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725203/?tool=EBI",
  "id": "51ca8by9mpf6q",
  "issns": [
    "2688-2663"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13725203",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2721|Liver physiology and pathology"
    ]
  ],
  "openalex": "W7225074452",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725203/pdf/?tool=EBI",
  "pmcid": "PMC13725203",
  "pmid": "42973788",
  "published": "2026-11-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/51ca8by9mpf6q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13725203",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13725203"
    },
    {
      "first_seen": "2026-11-04T12:23:38Z",
      "native_id": "PMC13725203",
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      "url": "https://doi.org/10.1002/mco2.71108"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver physiology and pathology",
      "subfield": "general"
    }
  ],
  "title": "Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets",
  "title_text": "Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:50Z",
  "url": "https://research.draconitic.com/paper/51ca8by9mpf6q",
  "venue": "MedComm",
  "versions": []
}