{
  "abstract": "Purpose: This study aimed to examine how preconception serum lipid profiles are associated with pregnancy complications in women who achieved singleton live births following assisted reproductive technology (ART).\n\nMethods: This study included 1,036 women who had singleton births after ART. Preconception serum lipid measurements included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). The pregnancy complication outcomes included cesarean section, gestational diabetes mellitus (GDM), preeclampsia, preterm delivery (PTD), small for gestational age (SGA), large for gestational age (LGA), low birthweight (LBW), macrosomia, and neonatal intensive care unit (NICU) admission.\n\nResults: The incidence of cesarean section, GDM, preeclampsia, PTD, SGA, LGA, LBW, macrosomia, and NICU admission was 51.6%, 3.8%, 0.7%, 7.6%, 6.8%, 15.6%, 6.4%, 5.7%, and 1.8%, respectively. Women with dyslipidemia had higher rates of GDM (11.7% vs. 2.1%, p < 0.001), PTD (13.9% vs. 6.3%, p < 0.001), and LWB (10.6% vs. 5.5%, p = 0.012). After adjusting for possible confounders, TG (OR 1.49[1.11–1.99]) was positively associated with PTD. TC (OR 1.48[1.08–2.02]), LDL-C (OR 1.48[1.03–2.14]), and HDL-C (OR 3.03[1.19–7.73]) were positively associated with SGA. TC (OR 2.22[1.63–3.04]) and TG (OR 1.20[1.00–1.44]) were positively associated with GDM.\n\nConclusion: Preconception serum lipid levels were associated with pregnancy complications in women receiving ART.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynecology, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China",
    "Department of Gynecology, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China",
    "Department of Gynecology, Zhejiang Hospital, Hangzhou, China",
    "Department of Gynecology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China",
    "Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China",
    "Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wang-Yu Cai"
    },
    {
      "affs": [
        1
      ],
      "name": "Xi Luo"
    },
    {
      "affs": [
        2
      ],
      "name": "Qing Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hongping Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Huadi Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyan Wang"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Jian Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/51ejncz0zk3qz.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1915181",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731389/",
  "id": "51ejncz0zk3qz",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://doi.org/10.3389/fnut.2026.1915181",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2735|Assisted Reproductive Technology and Twin Pregnancy"
    ]
  ],
  "openalex": "W7223089119",
  "pdf_url": "https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1915181/pdf",
  "pmcid": "PMC13731389",
  "pmid": "42985155",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/51ejncz0zk3qz.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:35Z",
      "native_id": "PMC13731389",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnut.2026.1915181"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Assisted Reproductive Technology and Twin Pregnancy",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Association between preconception serum lipid levels and pregnancy complications in singleton live births from IVF/ICSI with fresh embryo transfers",
  "title_text": "Association between preconception serum lipid levels and pregnancy complications in singleton live births from IVF/ICSI with fresh embryo transfers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:35Z",
  "url": "https://research.draconitic.com/paper/51ejncz0zk3qz",
  "venue": "Frontiers in Nutrition",
  "versions": []
}