{
  "abstract": "Background:: Nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NERD) is a chronic inflammatory condition clinically characterized by the triad of asthma, nasal polyps, and hypersensitivity reactions after aspirin ingestion. It is a distinct syndrome that is closely associated with eosinophilic infiltration of respiratory tissues and excessive production of cysteinyl leukotrienes. Research on NERD is characterized by fragmented knowledge, an incomplete understanding of its underlying mechanisms, and a lack of standardized approaches for its diagnosis and treatment. This study systematically summarized the major research directions and advances in identifying hotspots and emerging trends in NERD.\n\nMethods:: To address these challenges, we retrieved NERD-related literature from 2000 to 2024 from the Web of Science Core Collection and performed a bibliometric analysis using CiteSpace, VOSviewer, and Bibliometrix to help researchers quickly understand the field’s evolution and research frontiers.\n\nResults:: The analysis showed that, over the past 24 years, publication output in this field has grown steadily. Notably, the United States has made the largest contribution. At the institutional level, Jagiellonian University in Poland had the highest number of publications, and Professor Marek Sanak was identified as the most prolific author. The Journal of Allergy and Clinical Immunology was the most frequently cited journal in this field. Keyword co-occurrence and cluster analysis revealed that the current research themes focused on disease pathogenesis and treatment approaches. The journal dual-map overlay analysis further showed that research trends have gradually shifted from molecular biology and genetics to immunology and clinical research.\n\nConclusion:: This study provides important insights into the current status, advances, and emerging trends of NERD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China",
    "Department of Otolaryngology Head and Neck Surgery, Wushan County People’s Hospital of Chongqing, Chongqing, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chenxi Li",
      "orcid": "0009-0005-6480-8839"
    },
    {
      "affs": [
        0
      ],
      "name": "Dayu Guan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yalan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Bowen Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuchuan Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoling Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yucheng Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/51ydd0e0385jm.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051236",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727235/?tool=EBI",
  "id": "51ydd0e0385jm",
  "issns": [
    "0304-5412",
    "1536-5964",
    "0025-7974"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727235",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6000"
    ],
    [
      "heading",
      "Bibliometric Review"
    ],
    [
      "heading",
      "Research Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727235/pdf/?tool=EBI",
  "pmcid": "PMC13727235",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/51ydd0e0385jm.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727235",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727235"
    },
    {
      "first_seen": "2026-11-05T12:23:21Z",
      "native_id": "PMC13727235",
      "source": "pmc",
      "url": "https://doi.org/10.1097/md.0000000000051236"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Research and therapeutic status of NSAID-exacerbated respiratory disease : A bibliometric study from 2000 to 2024",
  "title_text": "Research and therapeutic status of NSAID-exacerbated respiratory disease : A bibliometric study from 2000 to 2024",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:57Z",
  "url": "https://research.draconitic.com/paper/51ydd0e0385jm",
  "venue": "Medicine",
  "versions": []
}