{
  "abstract": "Introduction\n\nEmotional dysregulation (ED), common among patients with psoriasis, leads to psychopathology and impairs treatment adherence.Objective\n\nThis study examined the changes in prevalence of ED in patients and its effects on illness perception, mental health, and quality of life (QoL) during one year of treatment with risankizumab.Method\n\nED, illness perception, general health, and QoL were measured at baseline, and at four, 16, and 52 weeks posttreatment in 58 patients with psoriasis.Results\n\nHigher ED was associated with greater psychological distress and poorer QoL. Patients with higher levels of ED reported greater psychological distress, worse QoL, and higher symptom-related distress throughout treatment as compared to those with lower ones. Although both groups improved in terms of illness perception and clinical severity outcomes, patients with high ED consistently experienced worse subjective outcomes.Conclusion\n\nED is frequent in psoriasis patients and negatively affects mental health and QoL, despite clinical improvements in skin symptoms. Targeted psychological interventions may be necessary for patients who exhibit higher levels of emotional dysregulation to ensure comprehensive care and better long-term outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Dermatology Department, IDI-IRCCS, Rome, Italy.",
    "Clinical Epidemiology, Clinical Psychology Unit, IDI-IRCCS, Rome, Italy.",
    "Asl Roma 2, Ospedale Sandro Pertini, Rome, Italy.",
    "San Gallicano Dermatological Institute, IRCCS, Rome, Italy.",
    "Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.",
    "Dermatology Unit, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.",
    "Dermatology Department, Ospedale di Belcolle, Viterbo, Italy.",
    "Dermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.",
    "Institute of Dermatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.",
    "Dermatology Unit, Sant'Andrea Hospital University of Rome, Rome, Italy.",
    "Dermatology Department, Ospedale San Sebastiano, Frascati, Roma, Italy.",
    "Clinical Dermatology Department, IDI-IRCCS, Capranica, Italy.",
    "Department of Plastic, Reconstructive and Cosmetic Surgery, Dermatology Unit, Campus Bio-Medico, Rome, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gaia Moretta"
    },
    {
      "affs": [
        1
      ],
      "name": "Tonia Samela"
    },
    {
      "affs": [
        2
      ],
      "name": "Alessia Provini"
    },
    {
      "affs": [
        0
      ],
      "name": "Gianluca Pagnanelli"
    },
    {
      "affs": [
        3
      ],
      "name": "Dario Graceffa"
    },
    {
      "affs": [
        3
      ],
      "name": "Diego Orsini"
    },
    {
      "affs": [
        3
      ],
      "name": "Viviana Lora"
    },
    {
      "affs": [
        4
      ],
      "name": "Antonio Giovanni Richetta"
    },
    {
      "affs": [
        4
      ],
      "name": "Annunziata Dattola"
    },
    {
      "affs": [
        4
      ],
      "name": "Simone Amato"
    },
    {
      "affs": [
        5
      ],
      "name": "Nicoletta Bernardini"
    },
    {
      "affs": [
        6
      ],
      "name": "Paola Tribuzi"
    },
    {
      "affs": [
        7
      ],
      "name": "Arianna Zangrilli"
    },
    {
      "affs": [
        7
      ],
      "name": "Martina Vultaggio"
    },
    {
      "affs": [
        7
      ],
      "name": "Luca Bianchi"
    },
    {
      "affs": [
        8
      ],
      "name": "Giacomo Caldarola"
    },
    {
      "affs": [
        8
      ],
      "name": "Eleonora De Luca"
    },
    {
      "affs": [
        8
      ],
      "name": "Clara De Simone"
    },
    {
      "affs": [
        9
      ],
      "name": "Domenico Giordano"
    },
    {
      "affs": [
        10
      ],
      "name": "Cinzia Masini"
    },
    {
      "affs": [
        10
      ],
      "name": "Mauro Bavetta"
    },
    {
      "affs": [
        11
      ],
      "name": "Stefania Lechiancole"
    },
    {
      "affs": [
        12
      ],
      "name": "Vincenzo Panasiti"
    },
    {
      "affs": [
        1
      ],
      "name": "Damiano Abeni"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/520w9tvws7z4e.bib",
  "cited_by": 0,
  "doi": "10.5826/dpc.1603a6163",
  "fulltext_url": "https://europepmc.org/articles/PMC13557251",
  "id": "520w9tvws7z4e",
  "issns": [
    "2160-9381"
  ],
  "landing_url": "https://europepmc.org/article/MED/42858446",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13557251?pdf=render",
  "pmcid": "PMC13557251",
  "pmid": "42858446",
  "published": "2026-07-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/520w9tvws7z4e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:18Z",
      "native_id": "MED:42858446",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42858446"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.",
  "title_text": "Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:18Z",
  "url": "https://research.draconitic.com/paper/520w9tvws7z4e",
  "venue": "Dermatology practical & conceptual",
  "versions": []
}